{"title":"Microwave-assisted synthesis of pyrrolidinyl-spirooxindoles via tandem 1,3-dipolar cycloaddition and oxidative dehydrogenation","authors":"Hong-bo Tan , Yu-heng Xiang , Jing-wen Huang , Si-ying Ren , Chang-qiu Lin , Zhi-gang Xu , Dian-yong Tang , Zhong-zhu Chen","doi":"10.1016/j.tet.2024.134379","DOIUrl":null,"url":null,"abstract":"<div><div>An oxidant-free, microwave-promoted tandem 1,3-dipolar cycloaddition and dehydrogenation oxidation is achieved under environmentally friendly conditions, delivering novel fused pyrrolidinyl-spirooxindoles in good to excellent yields. This work provides powerful means to expand the structural diversity of pyrrolidinyl-spirooxindole as a promising scaffold for novel drug discovery.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"169 ","pages":"Article 134379"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S004040202400560X","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
An oxidant-free, microwave-promoted tandem 1,3-dipolar cycloaddition and dehydrogenation oxidation is achieved under environmentally friendly conditions, delivering novel fused pyrrolidinyl-spirooxindoles in good to excellent yields. This work provides powerful means to expand the structural diversity of pyrrolidinyl-spirooxindole as a promising scaffold for novel drug discovery.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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