Could acute Q fever be causing some cases of pediatric acute encephalitis syndrome in eastern Uttar Pradesh?

The Microbe Pub Date : 2024-11-12 DOI:10.1016/j.microb.2024.100203

Shahzadi Gulafshan, Pooja Bhardwaj, Rohit Beniwal, Vishal Yadav, Rajni Kant, Kamran Zaman, Mahim Mittal, Bhoopendra Sharma, Vijai Kumar Srivastava, Rajeev Singh

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Abstract

Purpose

Q -fever is an underestimated zoonotic infection caused by Coxiella burnetii (CB). Humans are accidental host, and CB infection along with febrile illness also does neurological disorder. In India pediatric acute encephalitis syndrome (pAES) is reported very often from eastern Uttar Pradesh (E-UP), where, in 20–25 % of the cases, etiology remains unidentified. Therefore, we aim to investigate the seroprevalence for acute Q fever (AQF) among the hospitalized pAES patients, truly negative for other reported etiologies of the region by ELISA.

Pricipal results

Total 282 pAES cases were recruited in this study. Each case presented with fever, and vomiting. Further, a combination of one or more symptoms including headache, abnormal body movement, frothing from mouth, up-rolling eyeballs, and unconsciousness was observed in infected patients. In this study we have found 2.1 % (6/282) seroprevalence of P2 Coxiella burnetii IgM in studied cases.

Conclusion

The finding would assist clinicians in appropriate diagnosis of AES cases in India. Moreover, this study suggests further surveillance for CB infection among cases with neurological disorder.

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急性 Q 热可能是导致北方邦东部一些小儿急性脑炎综合征病例的原因吗？

目的Q热是由烧伤柯西氏菌（CB）引起的一种被低估的人畜共患传染病。人类是偶然的宿主，CB 感染除了会引起发热疾病外，还会导致神经系统紊乱。在印度，小儿急性脑炎综合征（pAES）经常见于北方邦东部（E-UP），其中 20-25% 的病例病因不明。因此，我们旨在调查通过 ELISA 检测该地区其他病原体呈阴性的住院 pAES 患者的急性 Q 热（AQF）血清流行率。每个病例都伴有发热和呕吐。此外，还观察到感染者同时出现头痛、异常肢体运动、口吐白沫、眼球上翻和昏迷等一种或多种症状。在这项研究中，我们发现所研究病例中 P2 烧伤柯西氏菌 IgM 血清阳性率为 2.1%（6/282）。此外，本研究还建议进一步监测神经系统疾病病例中的 CB 感染情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Microbe

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