Öznur Demir , Estere Oselska , Maris Bertins , Arturs Viksna , Aldo R. Boccaccini , Dagnija Loca
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引用次数: 0
Abstract
Calcium phosphate cements (CPCs) have been extensively utilized as bone grafting material due to their inherent osteoconductive properties, although they often lacked sufficient biological performance for effective bone healing at the defect site. Incorporating mesoporous bioactive glass (MBG) into CPCs offers a solution by improving porosity, promoting degradation and increasing the available surface area. In the scope of this study, we integrated MBG into CPCs and assessed the impact of varying MBG particle sizes (<20 µm, <38 µm, <100 µm) on the setting characteristics, microstructure, mechanical strength, and preliminary cell response of CPCs. Investigations revealed that < 20 µm MBG particles significantly improved the setting characteristics and compressive strength of CPCs, while < 38 µm particles promoted degradation and ion release, facilitating apatite formation. MBG incorporation was found to promote microstructural homogeneity and facilitate apatite formation, with particle size directly affecting these outcomes. Biocompatibility assessments indicated no cytotoxic effects, supported by the favorable cellular responses (> 92 % viability compared to control group). These findings underscore the critical impact of MBG particle size on developing advanced CPCs for biomedical applications, guiding future design and optimization strategies.
期刊介绍:
Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry.
The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.