Ezetimibe: Integrating Established Use with New Evidence - A Comprehensive Review.

IF 5.2 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Current Atherosclerosis Reports Pub Date : 2024-11-25 DOI:10.1007/s11883-024-01248-w
Elena Olmastroni, Stefano Scotti, Federica Galimberti, Sining Xie, Manuela Casula
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Abstract

Purpose of review: To consolidate key information on the efficacy and safety of ezetimibe, with a focus on the latest evidence.

Recent findings: While ezetimibe has long been used alongside statins to help achieve lipid goals when statins are insufficient or in statin-intolerant patients, recent studies confirm and extend its benefits. Ezetimibe, when added to statins, is now recognized as an effective option for high-risk cardiovascular patients. Additionally, for those intolerant to statins, it can be combined with bempedoic acid, offering significant LDL cholesterol reduction. Ezetimibe's favourable tolerability, with fewer side effects than statins, along with the availability of fixed-dose combinations, enhances both treatment efficacy and patient adherence. Overall, this review underscores ezetimibe's evolving role in lipid management, providing valuable guidance for optimizing cardiovascular risk reduction strategies.

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依折麦布:整合既有用途与新证据--全面综述》。
综述目的整合有关依折麦布疗效和安全性的关键信息,重点关注最新证据:长期以来,依折麦布一直与他汀类药物并用,在他汀类药物不足或他汀类药物不耐受的患者中帮助实现血脂目标,最近的研究证实并扩大了依折麦布的益处。依折麦布加入他汀类药物后,现已被公认为是高危心血管患者的有效选择。此外,对于那些不耐受他汀类药物的患者,它还可以与贝门冬氨酸联合使用,从而显著降低低密度脂蛋白胆固醇。与他汀类药物相比,依折麦布的耐受性较好,副作用较少,再加上可提供固定剂量的复方制剂,从而提高了治疗效果和患者的依从性。总之,这篇综述强调了依泽替米贝在血脂管理中不断发展的作用,为优化降低心血管风险的策略提供了宝贵的指导。
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来源期刊
CiteScore
9.00
自引率
3.40%
发文量
87
审稿时长
6-12 weeks
期刊介绍: The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
期刊最新文献
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