{"title":"Statin Use Not Linked to Rotator Cuff Retear After Arthroscopic Rotator Cuff Repair.","authors":"Kotaro Yamakado","doi":"10.1016/j.arthro.2024.11.066","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate the risk factors, including hyperlipidemia and statin use, on rotator cuff healing after arthroscopic repair.</p><p><strong>Methods: </strong>A retrospective review of prospectively collected cases who underwent arthroscopic rotator cuff repair was conducted. Total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG) levels, and the presence or absence of statin use and type of statins used (type 1 naturally-derived statins and type 2 synthetic statins) were reviewed. Repair integrity was determined according to the Sugaya classification assessed by MRI (types 4 and 5 were considered retear). Including serum lipid levels and statin use, potential risk factors for retear were tested using multivariate logistic regression.</p><p><strong>Results: </strong>Six hundred and twenty cases were evaluated. The mean age was 66.9 years; 348 were males, and 272 were females. The overall retear rate was 16.1%. There was no statistically significant difference in serum lipid levels among the categories of the Sugaya classification. Multivariate logistic regression analysis showed no association between serum lipid levels and odds ratio for retear: TC (OR, 1.00; p = 0.72), LDL (OR, 0.99; p = 0.44), and TG (OR, 1.00; p = 0.88). Statins did not have a statistically significant increase or decrease in odds: type 1 statin (OR, 0.3; p = 0.061) and type 2 statin (OR, 1.4; p = 0.26). Older age (OR, 1.1; p < .0001), male gender (OR, 1.8; p = 0.021), and large to massive cuff tear size (OR, 3.4; p < .0001) were significant risk factors.</p><p><strong>Conclusion: </strong>No association was found between serum lipid levels and retear after arthroscopic rotator cuff repair. Statin use was not a statistically significant factor for retears, but different trends were seen for type 1 and type 2 statins. Older age, male gender, and large to massive tears were significant risks for retears.</p><p><strong>Level of evidence: </strong>III; Retrospective Cohort Design; Prognosis Study.</p>","PeriodicalId":55459,"journal":{"name":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","volume":" ","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arthroscopy-The Journal of Arthroscopic and Related Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.arthro.2024.11.066","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: The purpose of this study was to evaluate the risk factors, including hyperlipidemia and statin use, on rotator cuff healing after arthroscopic repair.
Methods: A retrospective review of prospectively collected cases who underwent arthroscopic rotator cuff repair was conducted. Total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG) levels, and the presence or absence of statin use and type of statins used (type 1 naturally-derived statins and type 2 synthetic statins) were reviewed. Repair integrity was determined according to the Sugaya classification assessed by MRI (types 4 and 5 were considered retear). Including serum lipid levels and statin use, potential risk factors for retear were tested using multivariate logistic regression.
Results: Six hundred and twenty cases were evaluated. The mean age was 66.9 years; 348 were males, and 272 were females. The overall retear rate was 16.1%. There was no statistically significant difference in serum lipid levels among the categories of the Sugaya classification. Multivariate logistic regression analysis showed no association between serum lipid levels and odds ratio for retear: TC (OR, 1.00; p = 0.72), LDL (OR, 0.99; p = 0.44), and TG (OR, 1.00; p = 0.88). Statins did not have a statistically significant increase or decrease in odds: type 1 statin (OR, 0.3; p = 0.061) and type 2 statin (OR, 1.4; p = 0.26). Older age (OR, 1.1; p < .0001), male gender (OR, 1.8; p = 0.021), and large to massive cuff tear size (OR, 3.4; p < .0001) were significant risk factors.
Conclusion: No association was found between serum lipid levels and retear after arthroscopic rotator cuff repair. Statin use was not a statistically significant factor for retears, but different trends were seen for type 1 and type 2 statins. Older age, male gender, and large to massive tears were significant risks for retears.
Level of evidence: III; Retrospective Cohort Design; Prognosis Study.
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Nowhere is minimally invasive surgery explained better than in Arthroscopy, the leading peer-reviewed journal in the field. Every issue enables you to put into perspective the usefulness of the various emerging arthroscopic techniques. The advantages and disadvantages of these methods -- along with their applications in various situations -- are discussed in relation to their efficiency, efficacy and cost benefit. As a special incentive, paid subscribers also receive access to the journal expanded website.
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