{"title":"COVID-19 affects vitamin D metabolism in the kidney","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01481-5","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 12","pages":"355-355"},"PeriodicalIF":5.9000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lab Animal","FirstCategoryId":"97","ListUrlMain":"https://www.nature.com/articles/s41684-024-01481-5","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
COVID-19 于 2020 年成为全球大流行病。SARS-CoV-2 虽然源于呼吸系统，但可影响许多其他器官系统。严重的 COVID-19 患者通常会出现急性肾损伤。最近有研究报告称，COVID-19 患者体内参与肾脏维生素 D 代谢的蛋白质--megalin 的浓度降低。然而，COVID-19 期间megalin、维生素 D 代谢和肾损伤之间的关系尚不清楚。科学报告》（Scientific Reports）上的一项研究发现，在感染了 SARS-CoV-2 的 K18-hACE2 小鼠中，megalin 表达的减少似乎改变了维生素 D 在肾脏中的作用，尽管与对照组相比，受感染动物体内的维生素 D 水平保持不变。SARS-CoV-2感染会增加肿瘤坏死因子α的水平，这表明维生素D代谢异常。这些结果表明，明确维生素 D 在 COVID-19 患者肾脏中的局部作用对于更好地治疗 COVID-19 相关肾脏发病机制非常重要：Kurosaki, Y. et al.
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LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research.
LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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