Amantadine improves POCD symptoms

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2024-11-26 DOI:10.1038/s41684-024-01478-0

Jorge Ferreira

引用次数: 0

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

金刚烷胺可改善 POCD 症状

手术后，患者通常会出现认知障碍，即术后认知功能障碍（POCD）。术后认知功能障碍与麻醉药物的残留水平、危重疾病以及重大、继发或并发手术有关。手术后谷氨酸的增加以及 NMDA 和 AMPA 受体的抑制与中枢神经系统炎症级联的破坏有关。金刚烷胺是一种 NMDA 受体拮抗剂，可以防止与谷氨酸有关的神经毒性。脑行为研究》（Behavioural Brain Research）杂志上的一项研究评估了金刚烷胺与异丙酚联用对小鼠神经的潜在保护作用。在进行捏尾试验时，仅服用金刚烷胺组的动物疼痛反应略有延迟，这表明金刚烷胺具有镇痛作用。与仅使用异丙酚组相比，与异丙酚合用时，动物在莫里斯水迷宫任务中的认知表现有所改善。同时给药还能缩短异丙酚暴露后的恢复时间。这些结果表明，与金刚烷胺联合用药为未来治疗POCD开辟了潜在的途径：Alaçam, B. et al.477, 115290 (2024)

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.

期刊最新文献

Behavioral and neurophysiological effects of electrical stunning on zebrafish larvae Aerobic exercise improves concussion symptoms In vivo starvation metabolic adaptations Vaping mice Mito-NAD(P)H age clocks in C.elegans