Synergistic Bioactivity of Aegiceras corniculatum (L.) Blanco and Its Endophytic Fungus Aspergillus: Antioxidant, Antimicrobial, and Cytotoxic Effects.
Sharika Noshin, Rahul Dev Bairagi, Sadia Airin, Dipa Debnath, Md Sohanur Rahaman, Amit Kumar Acharzo, Most Nazmin Aktar, Mohammed Bourhia, Ahmad Mohammad Salamatullah, Md Amirul Islam
{"title":"Synergistic Bioactivity of Aegiceras corniculatum (L.) Blanco and Its Endophytic Fungus Aspergillus: Antioxidant, Antimicrobial, and Cytotoxic Effects.","authors":"Sharika Noshin, Rahul Dev Bairagi, Sadia Airin, Dipa Debnath, Md Sohanur Rahaman, Amit Kumar Acharzo, Most Nazmin Aktar, Mohammed Bourhia, Ahmad Mohammad Salamatullah, Md Amirul Islam","doi":"10.1007/s12013-024-01553-w","DOIUrl":null,"url":null,"abstract":"<p><p>The mangrove fungi provide a vast and unexplored source of diverse and unique chemicals and biological properties. The plant Aegiceras corniculatum (L.) Blanco and its endophytic fungus aspergillus species were collected from different sites of the Baleswar river region in Sundarban. Hence, we compared the antioxidant properties of the associated fungus ACSF-1 and the methanolic bark extract of Aegiceras corniculatum (MBAC) by measuring the total phenolic content (TPC), total flavonoid content (TFC), and DPPH free radical assay. Subsequently, antimicrobial activity was measured using the disc diffusion method, and cytotoxic activity was measured using the brine shrimp lethality bioassay. The results showed that MBAC has even more DPPH scavenging activity (IC<sub>50</sub> = 44.036 μg/mL), TPC (310.275 mg GAE/g), and TFC (66.275 mg QE/g) in comparison with DPPH scavenging activity (IC<sub>50</sub> = 92.542 μg/mL), TPC (234.832 mg GAE/g), and TFC (134.887 mg QE/g) in ACSF-1. The median lethal concentration value (LC<sub>50</sub>) of MBAC and ACSF-1 was found to be 43.93 μg/mL and 336.84 μg/mL, respectively. Moreover, MBAC showed a dose-dependent antimicrobial response to Escherichia coli and Staphylococcus aureus, whereas ACSF-1 was found to have activity against Bacillus subtilis and S. aureus. These results emphasize the unique pharmacological characteristics of both the plant and fungus, indicating their potential usefulness in various therapeutic fields.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":"1197-1206"},"PeriodicalIF":1.8000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biochemistry and Biophysics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12013-024-01553-w","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The mangrove fungi provide a vast and unexplored source of diverse and unique chemicals and biological properties. The plant Aegiceras corniculatum (L.) Blanco and its endophytic fungus aspergillus species were collected from different sites of the Baleswar river region in Sundarban. Hence, we compared the antioxidant properties of the associated fungus ACSF-1 and the methanolic bark extract of Aegiceras corniculatum (MBAC) by measuring the total phenolic content (TPC), total flavonoid content (TFC), and DPPH free radical assay. Subsequently, antimicrobial activity was measured using the disc diffusion method, and cytotoxic activity was measured using the brine shrimp lethality bioassay. The results showed that MBAC has even more DPPH scavenging activity (IC50 = 44.036 μg/mL), TPC (310.275 mg GAE/g), and TFC (66.275 mg QE/g) in comparison with DPPH scavenging activity (IC50 = 92.542 μg/mL), TPC (234.832 mg GAE/g), and TFC (134.887 mg QE/g) in ACSF-1. The median lethal concentration value (LC50) of MBAC and ACSF-1 was found to be 43.93 μg/mL and 336.84 μg/mL, respectively. Moreover, MBAC showed a dose-dependent antimicrobial response to Escherichia coli and Staphylococcus aureus, whereas ACSF-1 was found to have activity against Bacillus subtilis and S. aureus. These results emphasize the unique pharmacological characteristics of both the plant and fungus, indicating their potential usefulness in various therapeutic fields.
期刊介绍：
Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems
The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized.
Examples of subject areas that CBB publishes are:
· biochemical and biophysical aspects of cell structure and function;
· interactions of cells and their molecular/macromolecular constituents;
· innovative developments in genetic and biomolecular engineering;
· computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies;
· photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design
For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
