Clinical and Dermoscopic Comparison of the Efficacy and Safety of 5% Fluorouracil Topical Cream and 1% Niacinamide Topical Gel in the Treatment of Actinic Keratosis: A Randomized Controlled Trial.

IF 2.3 4区医学 Q2 DERMATOLOGY Journal of Cosmetic Dermatology Pub Date : 2024-11-26 DOI:10.1111/jocd.16676

Nazila Poostiyan, Mahbube Barati, Zabiholah Shahmoradi, Mina Saber

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Abstract

Background: Actinic keratosis (AK) is a common skin condition treated by dermatologists; however, the effectiveness, superiority, and potential side effects of current treatment protocols are still debated.

Aim: This study aimed to compare the effectiveness and safety of 5% fluorouracil topical cream and 1% niacinamide topical gel in patients with AK.

Methods: In a randomized clinical trial, 26 patients with 95 AK lesions were assigned to receive either 5% fluorouracil topical cream twice daily for 4 weeks or 1% niacinamide topical gel twice daily for 3 months. Photography and dermoscopy before and after treatment were used to evaluate the outcomes.

Results: The study included 26 patients who underwent randomization and treatment. Analysis of the improvement response after treatment through photography and dermoscopy scores, as well as patients' perspectives, showed that the fluorouracil group had significantly better outcomes than the niacinamide group. However, treatment complications including burning, itching, and erythema were significantly more frequent in the fluorouracil group than in the niacinamide group.

Conclusions: Although 5% fluorouracil cream is more effective than 1% niacinamide gel in treating AK lesions, it is also associated with more frequent side effects.

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5％氟尿嘧啶外用乳膏和 1％烟酰胺外用凝胶治疗日光性角化病的临床和皮肤镜疗效及安全性比较：随机对照试验

背景：目的：本研究旨在比较5%氟尿嘧啶外用乳膏和1%烟酰胺外用凝胶对AK患者的有效性和安全性：在一项随机临床试验中，26 名 95 例 AK 患者被分配接受 5%氟尿嘧啶外用乳膏治疗，每天两次，连续 4 周；或接受 1%烟酰胺外用凝胶治疗，每天两次，连续 3 个月。治疗前后的照片和皮肤镜检查用于评估疗效：研究共纳入 26 名患者，他们均接受了随机分配和治疗。通过摄影和皮肤镜评分以及患者的观点对治疗后的改善反应进行分析，结果显示氟尿嘧啶组的疗效明显优于烟酰胺组。然而，氟尿嘧啶组的治疗并发症（包括灼烧、瘙痒和红斑）明显多于烟酰胺组：结论：虽然 5%氟尿嘧啶乳膏比 1%烟酰胺凝胶治疗 AK 病变更有效，但其副作用也更频繁。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.