Association between hemoglobin levels and cerebral white matter volume in a general older Japanese population: the Iki-Iki study.

IF 2.4 3区医学 Q2 CLINICAL NEUROLOGY Neuroradiology Pub Date : 2024-11-26 DOI:10.1007/s00234-024-03512-x

Hiroki Yamamoto, Keita Watanabe, Shota Momma, Soichiro Tatsuo, Masashi Matsuzaka, Yoshinori Tamada, Tatsuya Mikami, Shigeyuki Nakaji, Shingo Kakeda

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Abstract

Purpose: Although previous studies have reported that hemoglobin levels can affect the brain, very few have focused on the association between hemoglobin levels and brain volume. We aimed to identify the influence of hemoglobin levels on brain volume measured using magnetic resonance imaging (MRI) in a large elderly population.

Methods: This cross-sectional study included 2153 participants (median age, 69 years; 60.2% female) who underwent 3T brain MRI. Multiple regression analyses were performed after adjusting for potential confounders. In the subgroup analyses, participants were divided into four groups according to sex and age threshold (lower age group [65-74] and higher age group [≥ 75]).

Results: After adjusting for potential confounders, total white matter volume reduction was found to be associated with decreased hemoglobin levels (females: standardized β = 0.059, [95% confidence interval (CI): 0.0032, 0.11], P = 0.038, males: standardized β = 0.069 [95% CI: -0.00023, 0.14], P = 0.051). This relationship was notable in younger age groups of both sexes. After adjustment, the total gray matter and hippocampal volumes were not significantly associated with hemoglobin levels.

Conclusion: Low hemoglobin levels may have deleterious effects on white matter volume, which diminishes with age.

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日本普通老年人群中血红蛋白水平与脑白质体积之间的关系：Iki-Iki 研究。

目的：尽管之前的研究报告称血红蛋白水平会影响大脑，但很少有研究关注血红蛋白水平与脑容量之间的关系。我们的目的是在大量老年人群中确定血红蛋白水平对磁共振成像（MRI）测量的脑容量的影响：这项横断面研究纳入了 2153 名接受 3T 脑磁共振成像的参与者（中位年龄 69 岁；60.2% 为女性）。在调整了潜在的混杂因素后进行了多元回归分析。在亚组分析中，根据性别和年龄阈值（低年龄组[65-74岁]和高年龄组[≥75岁]）将参与者分为四组：调整潜在混杂因素后发现，白质总体积减少与血红蛋白水平下降有关（女性：标准化β=0.059，[95% 置信区间（CI）：0.0032，0.11]，P=0.038；男性：标准化β=0.069 [95% CI：-0.00023，0.14]，P=0.051）。这种关系在较年轻的男女年龄组中都很明显。经调整后，灰质总量和海马体积与血红蛋白水平无明显关系：结论：低血红蛋白水平可能会对白质体积产生有害影响，而白质体积会随着年龄的增长而减小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.