Yujia Yang, Zhao Zhang, Anling Luo, Yiting Deng, Xuzi Li, Jing Ye, Li He, Muke Zhou
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引用次数: 0
Abstract
Objectives: The impact of artery geometry on intracranial atherosclerosis (ICAS) is unclear. To investigate the association between local artery geometry characteristics and middle cerebral atherosclerotic stenosis.
Methods: This was a case-control study. ICAS patients with more than 50% stenosis in one M1 pre-bifurcation segment but no significant stenosis on the other side were included. The stenosis degree, diameter, length, angle, and morphology (straight-shape, U-shape, and S-shape) of the M1 pre-bifurcation segments were measured by using digital subtraction angiography (DSA) combined with computed tomography angiography (CTA) and 3D reconstruction imaging. The geometry characteristics on both sides were compared. The conditional multivariate Logistics regression was used to investigate the association between stenotic sides and the geometry characteristics.
Result: A total of 133 patients, 266 M1 pre-bifurcation segments, were included. Compared with non-stenotic sides, stenotic sides showed smaller diameters (2.873 ± 0.456 mm vs. 2.993 ± 0.360 mm, P = 0.002) and larger tortuosity index (7.61% vs. 6.45%, P = 0.048). The S-shape M1 pre-bifurcation segment was independently associated with the stenotic sides (OR = 3.509, 95% CI 1.176-10.468, P = 0.024). The stenotic side was worse fitted to Murray's law (mean square error 0.326 vs. 0.313).
Conclusions: The morphology of the M1 pre-bifurcation segment was associated with middle cerebral atherosclerotic stenosis.
目的：动脉几何形状对颅内动脉粥样硬化（ICAS）的影响尚不清楚。探讨局部动脉几何特征与大脑中动脉粥样硬化性狭窄的关系。方法：采用病例-对照研究。ICAS患者一侧M1前分叉段狭窄超过50%，但另一侧无明显狭窄。采用数字减影血管造影（DSA）联合计算机断层血管造影（CTA）和三维重建成像技术测量M1前分叉段的狭窄程度、直径、长度、角度和形态（直形、u形、s形）。比较了两侧的几何特性。使用条件多元logistic回归来研究狭窄侧与几何特征之间的关系。结果：共纳入133例患者，266个M1前分叉节段。与非狭窄侧壁相比，狭窄侧壁直径更小（2.873±0.456 mm比2.993±0.360 mm, P = 0.002），弯曲指数更大（7.61%比6.45%,P = 0.048）。s形M1预分叉段与狭窄侧独立相关（OR = 3.509, 95% CI 1.176-10.468, P = 0.024）。狭窄侧更符合默里定律（均方误差0.326比0.313）。结论：M1前分叉段形态与大脑中动脉粥样硬化性狭窄有关。
期刊介绍：
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.
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