Pulse wave analysis as a tool to assess endothelial function following lipid lowering intervention in hypercholesterolemia

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE Microvascular research Pub Date : 2024-11-23 DOI:10.1016/j.mvr.2024.104772

Nik Nor Izah Nik Ibrahim , Aida Hanum Ghulam Rasool , Razlina Abdul Rahman , Maryam Azlan , Aniza Abd Aziz

{"title":"Pulse wave analysis as a tool to assess endothelial function following lipid lowering intervention in hypercholesterolemia","authors":"Nik Nor Izah Nik Ibrahim , Aida Hanum Ghulam Rasool , Razlina Abdul Rahman , Maryam Azlan , Aniza Abd Aziz","doi":"10.1016/j.mvr.2024.104772","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Pulse wave analysis (PWA) assesses endothelial dependent vasodilation (EDV) via the change in augmentation index (AIx) and has been used as a tool to assess endothelial function. However, its effectiveness in assessing the response to lipid lowering treatment has not been evaluated. The study aimed to describe and correlate the change in EDV following lipid lowering intervention in patients with hypercholesterolemia.</div></div><div><h3>Methods</h3><div>48 newly diagnosed patients with hypercholesterolemia underwent 6 months intervention with statin and/or therapeutic lifestyle changes (TLC) in clinical setting. Lipid profile measurement and endothelial function assessment using PWA were performed pre- and post-intervention.</div></div><div><h3>Results</h3><div>Significant reductions in low density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (non-HDL-C) and total cholesterol (TC) with corresponding significant improvement in EDV (2.94 ± 3.69 % to 7.50 ± 3.79 %, <em>p</em> < 0.001) were observed following intervention. Sub-analyses revealed greater LDL-C reductions and EDV improvements in the statin group compared to TLC. There was a significant inverse correlation between the change in EDV and the change in LDL-C after intervention (<em>r</em> = −0.298, <em>p</em> = 0.040).</div></div><div><h3>Conclusion</h3><div>Endothelial function assessed by PWA showed a parallel change with lipid profile pattern following lipid lowering intervention. The simple and non-invasive method may provide a potential tool for evaluating endothelial function and treatment outcomes in patients with hypercholesterolemia.</div></div>","PeriodicalId":18534,"journal":{"name":"Microvascular research","volume":"158 ","pages":"Article 104772"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microvascular research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026286224001213","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Pulse wave analysis (PWA) assesses endothelial dependent vasodilation (EDV) via the change in augmentation index (AIx) and has been used as a tool to assess endothelial function. However, its effectiveness in assessing the response to lipid lowering treatment has not been evaluated. The study aimed to describe and correlate the change in EDV following lipid lowering intervention in patients with hypercholesterolemia.

Methods

48 newly diagnosed patients with hypercholesterolemia underwent 6 months intervention with statin and/or therapeutic lifestyle changes (TLC) in clinical setting. Lipid profile measurement and endothelial function assessment using PWA were performed pre- and post-intervention.

Results

Significant reductions in low density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (non-HDL-C) and total cholesterol (TC) with corresponding significant improvement in EDV (2.94 ± 3.69 % to 7.50 ± 3.79 %, p < 0.001) were observed following intervention. Sub-analyses revealed greater LDL-C reductions and EDV improvements in the statin group compared to TLC. There was a significant inverse correlation between the change in EDV and the change in LDL-C after intervention (r = −0.298, p = 0.040).

Conclusion

Endothelial function assessed by PWA showed a parallel change with lipid profile pattern following lipid lowering intervention. The simple and non-invasive method may provide a potential tool for evaluating endothelial function and treatment outcomes in patients with hypercholesterolemia.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

脉搏波分析作为评估高胆固醇血症患者降脂干预后内皮功能的一种工具。

背景：脉搏波分析（PWA）通过增强指数（AIx）的变化评估内皮依赖性血管舒张（EDV），已被用作评估内皮功能的工具。然而，它在评估降脂治疗反应方面的有效性尚未得到评估。方法：48 名新诊断的高胆固醇血症患者在临床环境中接受了为期 6 个月的他汀类药物和/或治疗性生活方式改变（TLC）干预。结果：低密度脂蛋白显著降低，而高密度脂蛋白则明显降低：结果：低密度脂蛋白胆固醇（LDL-C）、非高密度脂蛋白胆固醇（non-HDL-C）和总胆固醇（TC）明显降低，EDV（2.94 ± 3.69 % 至 7.50 ± 3.79 %，P 结论：通过使用他汀类药物和/或治疗性生活方式改变（TLC）对内皮功能进行评估，发现干预前后内皮功能明显改善（2.94 ± 3.69 % 至 7.50 ± 3.79 %，P 结论）：通过 PWA 评估的内皮功能与降脂干预后的血脂谱模式呈平行变化。这种简单、无创的方法可为评估高胆固醇血症患者的内皮功能和治疗效果提供一种潜在的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.