Association between type 2 diabetes and periodontitis: a population-based study in the North Peru.

Q1 Medicine Wellcome Open Research Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI:10.12688/wellcomeopenres.23036.2

Marcela Mayta-Mayorga, Victoria Guerra-Rodríguez, Antonio Bernabe-Ortiz

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Abstract

Background: Periodontitis, one of the most common forms of periodontal disease, has been linked to several cardiovascular factors including metabolic syndrome and inflammatory processes. This study aimed to determine the association between type 2 diabetes mellitus (T2DM) and periodontitis in a representative sample of individuals in the north of Peru.

Materials and methods: Secondary data analysis using information of a population-based survey, enrolling subjects aged 35 to 69 years. The outcome was periodontitis, evaluated using a self-reported and validated 8-item questionnaire (≥5 points compatible with severe periodontitis), whereas the exposure was the presence of T2DM, evaluated using results of oral glucose tolerance test and categorized into two different forms: (a) normoglycemic, prediabetes, and T2DM, and (b) without T2DM, with T2DM and <5 years of diagnosis, and with T2DM and ≥5 years of diagnosis. Poisson regression models were utilized to report prevalence ratios (PR) and 95% confidence intervals (95% CI).

Results: Data from 1606 individuals were analyzed, with a mean age of 48.2 (SD: 10.6) years, and 50.3% were women. Of these, 272 (16.9%) had prediabetes and 176 (11.0%) had T2DM (71.6% with <5 years of disease). Overall, 97.0% presented at least one symptom compatible with periodontitis, 882 (55.0%) had mild, 643 (40.0%) had moderate, and 5% had severe periodontitis. In multivariable model, those with T2DM had a higher prevalence of severe periodontitis (PR = 1.99; 95% CI: 1.12 - 3.54). Similarly, those with <5 years of disease had a higher prevalence of severe periodontitis (PR = 2.48; 95% CI: 1.38 - 4.46).

Conclusions: Our research confirms the association between T2DM and severe periodontitis, especially among those with recent diagnosis (<5 years). Symptoms of periodontitis are quite common in our study population. Our results suggest a need to periodically assess oral health in patients with T2DM.

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2 型糖尿病与牙周炎之间的关系：一项基于秘鲁北部人口的研究。

背景：牙周炎是最常见的牙周疾病之一，与包括代谢综合征和炎症过程在内的多种心血管因素有关。本研究旨在确定秘鲁北部代表性样本中 2 型糖尿病（T2DM）与牙周炎之间的关联：利用一项人口调查的信息进行二次数据分析，调查对象的年龄在 35 岁至 69 岁之间。结果是牙周炎，使用自我报告和经过验证的 8 项调查问卷进行评估，而暴露是 T2DM 的存在，使用口服葡萄糖耐量试验的结果进行评估，并分为两种不同的形式：(a) 血糖正常、糖尿病前期和 T2DM，以及 (b) 无 T2DM、有 T2DM 和结果：分析了来自 1606 人的数据，他们的平均年龄为 48.2 岁（标准差：10.6），50.3% 为女性。其中，272 人（16.9%）患有糖尿病前期，176 人（11.0%）患有 T2DM（17.3% 伴有结论：我们的研究证实了 T2DM 与牙周炎之间的关联，尤其是在近期诊断出 T2DM 的患者中 (

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来源期刊

Wellcome Open Research Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

5.50

自引率

0.00%

发文量

426

审稿时长

1 weeks

期刊介绍： Wellcome Open Research publishes scholarly articles reporting any basic scientific, translational and clinical research that has been funded (or co-funded) by Wellcome. Each publication must have at least one author who has been, or still is, a recipient of a Wellcome grant. Articles must be original (not duplications). All research, including clinical trials, systematic reviews, software tools, method articles, and many others, is welcome and will be published irrespective of the perceived level of interest or novelty; confirmatory and negative results, as well as null studies are all suitable. See the full list of article types here. All articles are published using a fully transparent, author-driven model: the authors are solely responsible for the content of their article. Invited peer review takes place openly after publication, and the authors play a crucial role in ensuring that the article is peer-reviewed by independent experts in a timely manner. Articles that pass peer review will be indexed in PubMed and elsewhere. Wellcome Open Research is an Open Research platform: all articles are published open access; the publishing and peer-review processes are fully transparent; and authors are asked to include detailed descriptions of methods and to provide full and easy access to source data underlying the results to improve reproducibility.