{"title":"tRNA methylation drives early postnatal cardiomyocyte maturation","authors":"Pilar Ruiz-Lozano, Mark Mercola","doi":"10.1038/s44161-024-00572-3","DOIUrl":null,"url":null,"abstract":"The maturation of postnatal cardiomyocytes is vital for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 12","pages":"1375-1376"},"PeriodicalIF":10.8000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00572-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
The maturation of postnatal cardiomyocytes is vital for the heart to sustain pump activity through adulthood. The methyltransferase METTL1 drives cardiomyocyte maturation during the first week of postnatal life in the mouse by enhancing ketogenesis and fatty acid oxidation.
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