HLA class I and class II alleles and haplotypes of Algerian population from Algiers and neighbouring area.

Malika Bouali-Benhalima, Meriem Abbadi, Sarah Hamada, Celine Mandier, Souhila Amoura, Valérie Dubois, Sofiane Samir Salah
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Abstract

In this study, we aimed to investigate the current genetic diversity and provide additional insights into the origins of the Algerian population by analyzing the frequencies of HLA -A,-B,-DRB1,-DQB1 alleles and associated haplotypes. We analyzed 1,082 unrelated healthy Algerian individuals, who were potential kidney donors, recruited and assessed in the Immunology Department of CHU Mustapha in Algiers over a 10-year period (2009-2019). HLA genotyping was performed by Polymerase Chain Reaction Sequence Specific Primers (PCR-SSP). The allelic typing estimate and haplotype frequencies were calculated using the R studio® software and Haplotype frequency estimation from the website https://hla-net.eu/. We identified a total of 20 HLA-A alleles, 31 HLA-B alleles, 13 HLA-DRB1 alleles and5 HLA-DQB1 alleles. Regarding the allele frequency, the haplotype frequency and the distribution with other population database, we were able to provide a description of Algerian genetic background and draw some anthropogenetic conclusions. This study of HLA polymorphism in the Algerian population shows a strong genetic similarity with the populations of southern Europe and North Africa (Morocco, Tunisia and Libya) with which it has shared a common history since antiquity. In addition to its contribution to anthropogenetics, our study, serve as a reference database for studies exploring associations between the HLA system and certain pathologies.

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阿尔及尔及邻近地区阿尔及利亚人口的 HLA I 类和 II 类等位基因及单倍型。
在这项研究中,我们旨在通过分析 HLA -A、-B、-DRB1、-DQB1 等位基因和相关单倍型的频率,调查阿尔及利亚人口目前的遗传多样性,并为了解其起源提供更多信息。我们分析了 10 年间(2009 年至 2019 年)在阿尔及尔穆斯塔法医院免疫学部招募和评估的 1082 名可能捐献肾脏的非亲属关系健康阿尔及利亚人。HLA 基因分型通过聚合酶链式反应序列特异性引物(PCR-SSP)进行。使用 R studio® 软件计算等位基因分型估计值和单倍型频率,并通过网站 https://hla-net.eu/ 估算单倍型频率。我们共鉴定出 20 个 HLA-A 等位基因、31 个 HLA-B 等位基因、13 个 HLA-DRB1 等位基因和 5 个 HLA-DQB1 等位基因。关于等位基因频率、单倍型频率以及与其他人口数据库的分布情况,我们能够对阿尔及利亚的遗传背景进行描述,并得出一些人类遗传学结论。这项关于阿尔及利亚人口 HLA 多态性的研究表明,阿尔及利亚人口与南欧和北非(摩洛哥、突尼斯和利比亚)的人口在遗传方面有很强的相似性,阿尔及利亚自古以来就与这些国家有着共同的历史。除了对人类遗传学的贡献外,我们的研究还可作为研究 HLA 系统与某些病症之间关系的参考数据库。
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