The relationship between systemic inflammation response index and clinical and histopathological features in gastric cancer.

Hikmet Pehlevan-Özel, Tolga Dinç, Nermin D Okay, Mesut Tez
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Abstract

Objective: The systemic inflammation response index (SIRI) is a marker used to predict survival. The aim of this study is to examine the relationship between SIRI and clinicopathological features and survival.

Method: The relationship between clinicopathological characteristics and survey and SIRI was retrospectively investigated.

Results: A total of 178 patients were included in the study. Poor prognostic factors such as tumor size, t, T-stage, tumor-node-metastasis (TNM) stage, and CA19-9 level were found to have a statistically significant relationship with patients with high SIRI (p = 0.039, p = 0.001, p = 0.001 and p = 0.013, respectively). A high SIRI was found to be an independent and poor prognostic factor for 3-year and 5-year survival (p = 0.014 and p = 0.027, respectively).

Conclusions: High SIRI was associated with a poor survival rate, as were advanced TNM stage, advanced T stage, larger tumor size, and elevated CA19-9 level; all these are poor prognostic markers for gastric cancer.

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胃癌全身炎症反应指数与临床和组织病理学特征的关系
目的:全身炎症反应指数(SIRI)是一种用于预测生存率的指标。本研究旨在探讨 SIRI 与临床病理特征和生存率之间的关系:方法:回顾性研究临床病理特征和调查与 SIRI 之间的关系:结果:研究共纳入178例患者。研究发现,肿瘤大小、t、T期、肿瘤-结节-转移(TNM)分期和CA19-9水平等不良预后因素与高SIRI患者有显著统计学关系(分别为p = 0.039、p = 0.001、p = 0.001和p = 0.013)。高 SIRI 是 3 年和 5 年生存率的独立且不良预后因素(分别为 p = 0.014 和 p = 0.027):结论:SIRI高与生存率低有关,TNM分期晚期、T分期晚期、肿瘤体积较大和CA19-9水平升高也与生存率低有关;所有这些都是胃癌的不良预后标志物。
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