Unraveling the RNA code: a uridine RNA modification drives glycoRNA biogenesis

Abstract

In a recent Cell study, Xie et al.¹ introduce a novel mass spectrometry-based methodology for the sensitive detection and enrichment of native sialic acid-containing glycoRNA on cell surfaces. This work represents a significant advancement in the emerging field of glycoRNA biology. The authors linked acp³U, a modified uridine which was first described five decades ago, with RNA glycosylation in mammalian cells.