{"title":"Exploring gene expression in the maturing human brain at the single-cell level","authors":"","doi":"10.1038/s41588-024-01991-5","DOIUrl":null,"url":null,"abstract":"Advancements in single-cell analysis technologies are enabling exploration of the intricacies of the human brain at unprecedented resolution. However, most research thus far has focused on the adult brain. Here, these tools are applied to reveal cell-type-specific gene-expression dynamics as the brain grows from childhood to adulthood.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"247 1","pages":""},"PeriodicalIF":31.7000,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41588-024-01991-5","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Advancements in single-cell analysis technologies are enabling exploration of the intricacies of the human brain at unprecedented resolution. However, most research thus far has focused on the adult brain. Here, these tools are applied to reveal cell-type-specific gene-expression dynamics as the brain grows from childhood to adulthood.
期刊介绍：
Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation.
Integrative genetic topics comprise, but are not limited to:
-Genes in the pathology of human disease
-Molecular analysis of simple and complex genetic traits
-Cancer genetics
-Agricultural genomics
-Developmental genetics
-Regulatory variation in gene expression
-Strategies and technologies for extracting function from genomic data
-Pharmacological genomics
-Genome evolution
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