Quanjin Rong, Zhe Zhang, Jingyu Meng, Fan Wang, Zhongquan Liu
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引用次数: 0
Abstract
Previous methods for selective halogenation of aliphatic C-H bonds generally required catalysts, additives, and the use of large amounts of solvents, leading to low atom economy and solvent pollution issues. We report herein a visible-light-driven bromination/chlorination of 3o C(sp3)-H bonds without using any catalyst or solvent. This method can functionalize C-H bonds with high site selectivity and excellent functional group tolerance, even in complex molecules. Additionally, the reaction can be easily scaled up to gram-level production without losing efficiency.
期刊介绍：
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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