Rational Design of Self-Reporting Polymersomes for the Controlled Release of Sulfur Dioxide

IF 5.1 Q1 POLYMER SCIENCE ACS Macro Letters Pub Date : 2024-11-27 DOI:10.1021/acsmacrolett.4c00687
Zhezhe Li, Yue Zhang, Suzhen Wang, Yihan Wu, Hailong Che
{"title":"Rational Design of Self-Reporting Polymersomes for the Controlled Release of Sulfur Dioxide","authors":"Zhezhe Li, Yue Zhang, Suzhen Wang, Yihan Wu, Hailong Che","doi":"10.1021/acsmacrolett.4c00687","DOIUrl":null,"url":null,"abstract":"As a new member of the gaseous regulators, sulfur dioxide (SO<sub>2</sub>) plays a crucial role in many biological activities. Recent studies have shown that SO<sub>2</sub> is capable of inducing cancer cell apoptosis by regulating intracellular reactive oxygen species (ROS), allowing SO<sub>2</sub> to serve as an efficient therapeutic agent. Although various polymer-based platforms have presented great potential for the controlled release of SO<sub>2</sub>, most of the systems are incapable of monitoring the intracellular generation of SO<sub>2</sub>. In this work we present the rational design of SO<sub>2</sub>-releasing biodegradable polymersomes, accompanied by a self-reporting property. The polymersome consists of a hydrophilic block of poly(ethylene glycol) (PEG) and a hydrophobic segment of poly(trimethylene carbonate) (PTMC)-based SO<sub>2</sub> donors. The polymersomes not only exhibit good SO<sub>2</sub>-releasing performance upon treatment with glutathione (GSH), but can also regulate the fluorescence change of the system, offering a good platform for real-time monitoring of the intracellular production of SO<sub>2</sub>. Significantly, the <i>in vitro</i> and <i>in vivo</i> studies indicate the potential for exploitation of these polymersomes as antitumor agents. We expect that incorporating both the SO<sub>2</sub>-releasing capacity and self-reporting feature within a polymersome system will provide a unique opportunity for the development of intelligent gas nanovehicles.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"258 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Macro Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acsmacrolett.4c00687","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

Abstract

As a new member of the gaseous regulators, sulfur dioxide (SO2) plays a crucial role in many biological activities. Recent studies have shown that SO2 is capable of inducing cancer cell apoptosis by regulating intracellular reactive oxygen species (ROS), allowing SO2 to serve as an efficient therapeutic agent. Although various polymer-based platforms have presented great potential for the controlled release of SO2, most of the systems are incapable of monitoring the intracellular generation of SO2. In this work we present the rational design of SO2-releasing biodegradable polymersomes, accompanied by a self-reporting property. The polymersome consists of a hydrophilic block of poly(ethylene glycol) (PEG) and a hydrophobic segment of poly(trimethylene carbonate) (PTMC)-based SO2 donors. The polymersomes not only exhibit good SO2-releasing performance upon treatment with glutathione (GSH), but can also regulate the fluorescence change of the system, offering a good platform for real-time monitoring of the intracellular production of SO2. Significantly, the in vitro and in vivo studies indicate the potential for exploitation of these polymersomes as antitumor agents. We expect that incorporating both the SO2-releasing capacity and self-reporting feature within a polymersome system will provide a unique opportunity for the development of intelligent gas nanovehicles.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
合理设计用于控制二氧化硫释放的自报告聚合体
作为气体调节剂的新成员,二氧化硫(SO2)在许多生物活动中发挥着至关重要的作用。最新研究表明,二氧化硫能够通过调节细胞内活性氧(ROS)诱导癌细胞凋亡,从而使二氧化硫成为一种有效的治疗剂。虽然各种基于聚合物的平台在控制释放二氧化硫方面具有巨大潜力,但大多数系统都无法监测细胞内二氧化硫的生成。在这项工作中,我们合理地设计了可释放二氧化硫的生物可降解聚合体,这种聚合体具有自我报告的特性。聚合体由聚(乙二醇)(PEG)亲水块和基于 SO2 供体的聚(三亚甲基碳酸酯)(PTMC)疏水段组成。经谷胱甘肽(GSH)处理后,聚合体不仅具有良好的二氧化硫释放性能,还能调节系统的荧光变化,为实时监测细胞内二氧化硫的产生提供了一个良好的平台。重要的是,体外和体内研究表明,这些聚合体有可能被用作抗肿瘤药物。我们预计,将二氧化硫释放能力和自我报告功能结合到聚合体系统中,将为开发智能气体纳米粒子提供一个独特的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
10.40
自引率
3.40%
发文量
209
审稿时长
1 months
期刊介绍: ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.
期刊最新文献
Rational Design of Self-Reporting Polymersomes for the Controlled Release of Sulfur Dioxide A Macrocycle-Mediated Protein Cage Enhancing Mechanophore Activation through Polymer Crystallization Influence of Solvent Dielectric Constant on the Complex Coacervation Phase Behavior of Polymerized Ionic Liquids. Issue Editorial Masthead
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1