Preparation and properties of inclusion complex of resveratrol with epichlorohydrin-modified β-cyclodextrin

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Letters Pub Date : 2024-11-26 DOI:10.1016/j.matlet.2024.137780

Shide Li , Hongsheng Luo , Ronghua Qiu , Kaibin Huang , Ziying Chen , Xiangjun Fu

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Abstract

In order to improve the aqueous solubility and enhance stability of resveratrol (RES), an inclusion complex (RES-ECH-βCD) of RES with epichlorohydrin-modified β-cyclodextrin (ECH-βCD) was prepared using freeze-drying. The effects of RES-ECH-βCD on the solubility and stability of RES were investigated. Phase solubility studies indicated that ECH-βCD significantly enhanced the solubility of RES compared to β-cyclodextrin (β-CD). Thermal stability tests showed that the inclusion complex exhibited superior thermal stability compared to free RES. Furthermore, the application of RES-ECH-βCD in sunscreen formulations was validated. The formulation exhibited sun protection properties, with RES-ECH-βCD working synergistically with α-glucosyl rutin (Rutin-G) to significantly enhance both SPF and PFA. These findings suggest that RES-ECH-βCD not only improves the solubility and stability of RES but also has promising potential for use in cosmetic and sunscreen products.

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白藜芦醇与环氧氯丙烷改性β-环糊精包合物的制备及其特性

为了提高白藜芦醇（RES）的水溶性和稳定性，本研究采用冷冻干燥法制备了白藜芦醇与环氧氯丙烷修饰的β-环糊精（ECH-βCD）的包合物（RES-ECH-βCD）。研究了 RES-ECH-βCD 对 RES 溶解性和稳定性的影响。相溶解度研究表明，与β-环糊精（β-CD）相比，ECH-βCD 能显著提高 RES 的溶解度。热稳定性测试表明，与游离 RES 相比，包合物具有更高的热稳定性。此外，还验证了 RES-ECH-βCD 在防晒配方中的应用。该配方具有防晒特性，RES-ECH-βCD 与 α-葡萄糖基芦丁（Rutin-G）协同作用，显著提高了 SPF 值和 PFA 值。这些研究结果表明，RES-ECH-βCD 不仅能提高 RES 的溶解度和稳定性，还具有在化妆品和防晒产品中使用的巨大潜力。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive