Spatial distribution and stability of Gd0.6Eu0.4VO4 nanoparticles injected in mouse ear pinnae

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL Trends in Analytical Chemistry Pub Date : 2024-11-16 DOI:10.1016/j.trac.2024.118049

Eleni Proiou , Fani Pinakidou , Eleni C. Paloura , Nicolas Pétri , Thierry Gacoin , Corinne Laplace-Builhé , Götz Schuck , Antigoni Alexandrou , Maria Katsikini

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Abstract

X-Ray Fluorescence (XRF) mapping is employed for the study of the spatial distribution of GdVO₄:Eu nanoparticles (NPs) after their injection into mouse ear pinnae. The injected NP colloids were detectable in a concentration range from 5 to 30 mM in vanadate ions (90–530 nM in NP concentrations). The distribution maps were recorded separately for Gd, Eu, and V and reveal that the three elements are collocalized, indicating the NP stability after the injection. The distribution pattern of the NPs is not homogeneous; they follow bifurcated paths of easy flow demonstrating the complexity of the tissue-colloid interactions. The V–K, Gd-L₃ and Eu-L₃-edge X-ray Absorption Fine Structure (XAFS) spectra of the NPs recorded prior to and after their injection confirm that the integrity of the nanoparticles is preserved after injection. This combined XRF/XAFS analysis paves the way for studies on the long-term fate of injected Gd-containing NPs in tissues.

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注入小鼠耳廓的 Gd0.6Eu0.4VO4 纳米粒子的空间分布和稳定性

采用 X 射线荧光 (XRF) 测绘法研究了 GdVO4:Eu 纳米粒子（NPs）注入小鼠耳廓后的空间分布。注入的 NP 胶体可在 5 至 30 mM 的钒酸盐离子浓度范围（NP 浓度为 90-530 nM）内检测到。分别记录钆、欧和钒的分布图显示，这三种元素是共聚焦的，表明注射后的 NP 具有稳定性。NPs 的分布模式并不均匀；它们遵循易于流动的分叉路径，显示了组织-胶体相互作用的复杂性。纳米粒子在注射前后记录的 V-K、Gd-L3 和 Eu-L3 边沿 X 射线吸收精细结构 (XAFS) 光谱证实，纳米粒子在注射后保持了完整性。这种 XRF/XAFS 组合分析为研究注射的含钆 NPs 在组织中的长期归宿铺平了道路。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.