Preparation and solid-state characterization of two novel berberine chloride cocrystals with benzene derivatives

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Structure Pub Date : 2024-11-19 DOI:10.1016/j.molstruc.2024.140808

Qingyi He , Tianyi Xiang , Shuyu Liu , Changquan Calvin Sun

引用次数: 0

Abstract

In this study, two novel salt-cocrystals of berberine chloride (BCl) with structurally similar benzene derivatives, i.e., 3-hydroxybenzoic acid (3HBA) and isophthalic acid (IA), were prepared. Their solid-state properties were characterized by complementary techniques, including single-crystal and powder X-ray diffractometry, thermogravimetric-differential scanning calorimetry, Fourier-transformed infrared spectroscopy, and dynamic moisture sorption analysis. Both cocrystals had lower hygroscopicity than BCl. An analysis of the properties of these cocrystals along with a previously published berberine chloride-resorcinol cocrystal suggests that a greater number of hydroxyl groups in these cocrystal formers may favor faster dissolution, measured by both intrinsic dissolution rate and powder dissolution.

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两种新型氯化小檗碱与苯衍生物共晶体的制备及固态表征

本研究制备了氯化小檗碱（BCl）与结构相似的苯衍生物（即 3-hydroxybenzoic acid (3HBA) 和 isophthalic acid (IA)）的两种新型盐类晶体。通过单晶和粉末 X 射线衍射测定法、热重-差示扫描量热法、傅立叶变换红外光谱法和动态水分吸附分析等辅助技术对它们的固态性质进行了表征。这两种共晶体的吸湿性都低于 BCl。对这些共晶体的性质以及之前发表的氯化小檗碱-间苯二酚共晶体的分析表明，这些共晶体形成物中的羟基数量越多，溶解速度就越快，这可以通过内在溶解速度和粉末溶解速度来衡量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.