Anti-infective Ti-Cu alloy inhibits bacterial drug resistance

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Letters Pub Date : 2024-11-16 DOI:10.1016/j.matlet.2024.137736

Zhiqiang Xu , Min Liu , Na Zhao , Guocai Chen , Weicheng Lu , Haixin Li , Yuanyan Wu , Hao Tan , Chunguang Yang , Xinrui Zhang

{"title":"Anti-infective Ti-Cu alloy inhibits bacterial drug resistance","authors":"Zhiqiang Xu , Min Liu , Na Zhao , Guocai Chen , Weicheng Lu , Haixin Li , Yuanyan Wu , Hao Tan , Chunguang Yang , Xinrui Zhang","doi":"10.1016/j.matlet.2024.137736","DOIUrl":null,"url":null,"abstract":"<div><div>Implant-associated infection is mainly conducted with antibiotics in clinic. However, the overuse and abuse of antibiotics contributes to resistant infections, increasing the difficulty of treatment. In this work, we initially investigate the effect of anti-infective Ti-Cu alloy incorporating with antibiotics (ciprofloxacin) to inhibit <em>methicillin-resistant Staphylococcus aureus</em> (MRSA) infections. Results show that, for Drug + Ti-Cu alloy group, the minimum inhibitory concentration (MIC) of antibiotics reduces by 76.00 %, minimum bactericidal concentration (MBC) reduces by 75.00 % and IC<sub>50</sub> reduces by 77.77 %. Scanning electron microscope (SEM) and laser confocal scanning microscope (CLSM) observations demonstrate that Ti-Cu alloy inhibits biofilms, including inhibiting bacterial activity and extracellular polymer substrates (EPS) secretion. We conclude high redox oxygen species (ROS) expression contributes to the excellent anti-infection capabilities of Ti-Cu alloy. Our work opens an avenue for addressing persistent drug resistant bacterial infections.</div></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":"379 ","pages":"Article 137736"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X24018767","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Implant-associated infection is mainly conducted with antibiotics in clinic. However, the overuse and abuse of antibiotics contributes to resistant infections, increasing the difficulty of treatment. In this work, we initially investigate the effect of anti-infective Ti-Cu alloy incorporating with antibiotics (ciprofloxacin) to inhibit methicillin-resistant Staphylococcus aureus (MRSA) infections. Results show that, for Drug + Ti-Cu alloy group, the minimum inhibitory concentration (MIC) of antibiotics reduces by 76.00 %, minimum bactericidal concentration (MBC) reduces by 75.00 % and IC₅₀ reduces by 77.77 %. Scanning electron microscope (SEM) and laser confocal scanning microscope (CLSM) observations demonstrate that Ti-Cu alloy inhibits biofilms, including inhibiting bacterial activity and extracellular polymer substrates (EPS) secretion. We conclude high redox oxygen species (ROS) expression contributes to the excellent anti-infection capabilities of Ti-Cu alloy. Our work opens an avenue for addressing persistent drug resistant bacterial infections.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

抗感染钛铜合金可抑制细菌耐药性

种植体相关感染在临床上主要使用抗生素。然而，抗生素的过度使用和滥用导致了耐药性感染，增加了治疗难度。在这项工作中，我们初步研究了抗感染钛铜合金与抗生素（环丙沙星）结合抑制耐甲氧西林金黄色葡萄球菌（MRSA）感染的效果。结果表明，在药物 + Ti-Cu 合金组中，抗生素的最低抑菌浓度（MIC）降低了 76.00%，最低杀菌浓度（MBC）降低了 75.00%，IC50 降低了 77.77%。扫描电子显微镜（SEM）和激光共聚焦扫描显微镜（CLSM）的观察结果表明，钛铜合金可抑制生物膜，包括抑制细菌活性和细胞外聚合物底物（EPS）的分泌。我们的结论是，氧化还原氧（ROS）的高表达有助于钛铜合金发挥出色的抗感染能力。我们的工作为解决持久性耐药细菌感染开辟了一条途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive