Influence of Batrachochytrium dendrobatidis isolate and dose on infection outcomes in a critically endangered Australian amphibian

IF 1.9 3区环境科学与生态学 Q3 ECOLOGY Fungal Ecology Pub Date : 2024-11-27 DOI:10.1016/j.funeco.2024.101397

Mikaeylah J. Davidson, Tiffany A. Kosch, Amy Aquilina, Rebecca J. Webb, Lee F. Skerratt, Lee Berger

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Abstract

The amphibian chytrid fungus (Batrachochytrium dendrobatidis (Bd)) is a continuing threat globally, causing widespread declines. Corroboree frogs (Pseudophryne corroboree) are critically endangered and no longer have self-sustaining populations in the wild due to the presence of Bd in the environment. We aimed to investigate variation in susceptibility to Bd in juvenile P. corroboree and evaluate the impact of Bd isolate and dose on infection outcomes. We experimentally exposed juvenile P. corroboree to two Bd isolates at five doses, and also characterised the in vitro growth of these isolates. Frogs showed high susceptibility to Bd, with isolate and dose impacting survival time and infection loads. Additionally, differences in the in vitro phenotype of the two Bd isolates were linked to their differential virulence. This study highlights the considerable impact that fungal isolate and dose have in shaping disease outcomes in experimental exposures.

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一种极度濒危的澳大利亚两栖动物感染树突蝙蝠蚴的分离株和剂量对感染结果的影响

两栖动物糜烂真菌（Batrachochytrium dendrobatidis (Bd)）是全球范围内的一种持续威胁，导致两栖动物数量普遍下降。珊瑚蛙（Pseudophryne corroboree）已极度濒危，由于环境中存在 Bd，其野外种群已无法自我维持。我们的目的是调查幼年克洛伯蛙对 Bd 的敏感性差异，并评估 Bd 分离物和剂量对感染结果的影响。我们在实验中将两种 Bd 分离物以五种剂量暴露于幼蛙，并分析了这些分离物的体外生长特征。蛙类对 Bd 的易感性很高，分离株和剂量会影响存活时间和感染量。此外，两种 Bd 分离物体外表型的差异与它们不同的毒力有关。这项研究强调了真菌分离株和剂量对实验暴露中疾病结果的影响。

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来源期刊

Fungal Ecology 环境科学-生态学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

3 months

期刊介绍： Fungal Ecology publishes investigations into all aspects of fungal ecology, including the following (not exclusive): population dynamics; adaptation; evolution; role in ecosystem functioning, nutrient cycling, decomposition, carbon allocation; ecophysiology; intra- and inter-specific mycelial interactions, fungus-plant (pathogens, mycorrhizas, lichens, endophytes), fungus-invertebrate and fungus-microbe interaction; genomics and (evolutionary) genetics; conservation and biodiversity; remote sensing; bioremediation and biodegradation; quantitative and computational aspects - modelling, indicators, complexity, informatics. The usual prerequisites for publication will be originality, clarity, and significance as relevant to a better understanding of the ecology of fungi.