Venous thromboembolism in patients with hairy cell leukemia.

IF 2 4区 医学 Q3 HEMATOLOGY Hematology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI:10.1080/16078454.2024.2431405
Lauren Peralta, Muneer Khan, Marcelle G Meseeha, Julie L Richards, Joyson Poulose, Giampaolo Talamo
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Abstract

Background: Hairy cell leukemia (HCL) is rare leukemia of mature B cells, accounting for 2% of all lymphoid neoplasms. Although the association of venous thromboembolism (VTE) with cancer is well established, there is no systematic study describing VTE in HCL.

Aim: To analyze prevalence and risk factors associated with VTE in HCL patients.

Methods: We retrospectively reviewed data from the medical records of 56 consecutive HCL patients evaluated in our Hematology/Oncology clinic between 1998 and 2023.

Results: The median age at diagnosis was 59 years (range, 37-94), and 49 patients (87%) were male. With a median follow-up of 122 months (1-291), we identified 11 episodes of VTE in 8 (14%) HCL patients: pulmonary embolism (PE) (5 cases) with or without concurrent deep venous thrombosis (DVT), and DVT alone (6 cases). All thrombotic episodes occurred after the diagnosis of HCL, or at the same time of it, as presenting clinical manifestation of the HCL. Risk factors for VTE other than cancer were identified in only 3 patients.

Conclusion: Our study found a high incidence of VTE in patients with HCL, mostly in the absence of other provoking factors, suggesting that this hematologic malignancy is associated with an underlying thrombophilic state.

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毛细胞白血病患者的静脉血栓栓塞。
背景:毛细胞白血病(HCL)是一种罕见的成熟 B 细胞白血病:毛细胞白血病(HCL)是一种罕见的成熟B细胞白血病,占所有淋巴肿瘤的2%。尽管静脉血栓栓塞症(VTE)与癌症的关系已被证实,但目前还没有系统研究描述 HCL 患者中的 VTE:我们回顾性审查了 1998 年至 2023 年间在血液学/肿瘤学诊所接受评估的 56 名连续 HCL 患者的病历数据:诊断时的中位年龄为 59 岁(37-94 岁),49 名患者(87%)为男性。中位随访时间为122个月(1-291个月),我们在8例(14%)HCL患者中发现了11次VTE发作:肺栓塞(PE)(5例)伴有或不伴有深静脉血栓形成(DVT),以及单纯深静脉血栓形成(6例)。所有血栓发作都发生在 HCL 诊断之后或同时,作为 HCL 的临床表现。除癌症外,仅在 3 例患者中发现了导致 VTE 的风险因素:我们的研究发现,HCL 患者的 VTE 发生率很高,而且大多没有其他诱发因素,这表明这种血液系统恶性肿瘤与潜在的嗜血栓状态有关。
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来源期刊
Hematology
Hematology 医学-血液学
CiteScore
2.60
自引率
5.30%
发文量
140
审稿时长
3 months
期刊介绍: Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.
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