Impairments of attention in RRMS patients: the role of disease duration.

Abstract

Introduction: The extent to which different types of attention are affected in RRMS based on disease duration has not been extensively analyzed. Therefore, the aim of this study was to determine whether MS patients differ compared to healthy individuals in a homogeneous sample of RRMS patients in terms of attention types and from which year of MS attention deficit starts. Another aim of the study was to examine the effect of MS duration and stimulus onset asynchrony on dual task performance.

Methods: The sample consisted of RRMS patients (n = 53) and healthy participants (n = 30) between the ages of 20-49, who were at least primary school graduates. Healthy participants in the comparison group were reached by snowball sampling technique. Stroop Test, Cancellation Test, Paced Auditory Serial Addition Test, Coding Test, WMS-R Digit Span and Visual Memory Span subtests were administered to assess attention. Divided attention performance was assessed with a dual task developed based on psychological refractory period paradigm.

Results: The results show that there is a significant difference between RRMS patients and healthy participants in terms of different types of attention (p < 0.05). Focused, sustained and divided attention of RRMS patients and the ability to resist interference showed a significant decline from the 7th year of the disease (p < 0.05); no significant difference was found between healthy participants and patients with 1-6 years of RRMS.

Conclusions: Although the results of the study are consistent with the literature which show that attention deficit develops in MS, it is important in terms of showing that attention deficit changes depending on the duration of the disease. Focused attention, sustained attention, interference resistance and divided attention performance of RRMS patients showed a significant decline after the 7th year of the disease.