Within-host dynamics of antiviral treatment with remdesivir for SARS-CoV-2 infection.

IF 3.7 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI:10.1098/rsif.2024.0536
Lea Schuh, Peter V Markov, Ioanna Voulgaridi, Zacharoula Bogogiannidou, Varvara A Mouchtouri, Christos Hadjichristodoulou, Nikolaos I Stilianakis
{"title":"Within-host dynamics of antiviral treatment with remdesivir for SARS-CoV-2 infection.","authors":"Lea Schuh, Peter V Markov, Ioanna Voulgaridi, Zacharoula Bogogiannidou, Varvara A Mouchtouri, Christos Hadjichristodoulou, Nikolaos I Stilianakis","doi":"10.1098/rsif.2024.0536","DOIUrl":null,"url":null,"abstract":"<p><p>The effectiveness of antiviral treatment with remdesivir against COVID-19 has been investigated in clinical trials suggesting earlier recovery. However, this effect seems to be rather modest. In this study, we tracked the clinical course of SARS-CoV-2 infections in 369 COVID-19 individuals across a spectrum of illness severities, including both untreated individuals and individuals who received antiviral treatment with remdesivir. Moreover, using a process-based mathematical model, we quantified and analysed the within-host infection dynamics of a total of 88 individuals, of which 69 were untreated and 19 antiviral-treated individuals. For untreated individuals, we found that those hospitalized exhibit lower levels of early immune response and higher cumulative viral loads than those who were not. For treated individuals, we found that those who died were on average hospitalized later after symptom onset than those who survived, underscoring the importance of early medical intervention for severe COVID-19. Finally, our model estimates a rather limited antiviral activity of remdesivir. Our results provide valuable insights into the clinical course of COVID-19 during antiviral treatment with remdesivir and suggest the need for alternative treatment regimens.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240536"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597410/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Royal Society Interface","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1098/rsif.2024.0536","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

The effectiveness of antiviral treatment with remdesivir against COVID-19 has been investigated in clinical trials suggesting earlier recovery. However, this effect seems to be rather modest. In this study, we tracked the clinical course of SARS-CoV-2 infections in 369 COVID-19 individuals across a spectrum of illness severities, including both untreated individuals and individuals who received antiviral treatment with remdesivir. Moreover, using a process-based mathematical model, we quantified and analysed the within-host infection dynamics of a total of 88 individuals, of which 69 were untreated and 19 antiviral-treated individuals. For untreated individuals, we found that those hospitalized exhibit lower levels of early immune response and higher cumulative viral loads than those who were not. For treated individuals, we found that those who died were on average hospitalized later after symptom onset than those who survived, underscoring the importance of early medical intervention for severe COVID-19. Finally, our model estimates a rather limited antiviral activity of remdesivir. Our results provide valuable insights into the clinical course of COVID-19 during antiviral treatment with remdesivir and suggest the need for alternative treatment regimens.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
用雷米地韦对 SARS-CoV-2 感染进行抗病毒治疗的宿主内动态变化。
在临床试验中,对使用雷米替韦对 COVID-19 进行抗病毒治疗的效果进行了调查,结果表明,这种治疗可以使患者更早地康复。然而,这种效果似乎并不明显。在这项研究中,我们跟踪了 369 名 COVID-19 感染者不同病情严重程度的 SARS-CoV-2 临床病程,包括未接受治疗者和接受雷米替韦抗病毒治疗者。此外,我们使用基于过程的数学模型,量化并分析了 88 人的宿主内感染动态,其中 69 人未经治疗,19 人接受了抗病毒治疗。对于未接受治疗的患者,我们发现,与未接受治疗的患者相比,住院患者的早期免疫反应水平较低,累积病毒载量较高。对于接受过治疗的患者,我们发现与存活者相比,死亡者在症状出现后住院的时间平均较晚,这突出了早期医疗干预对重症 COVID-19 的重要性。最后,我们的模型估计雷米替韦的抗病毒活性相当有限。我们的研究结果为了解雷米替韦抗病毒治疗期间 COVID-19 的临床病程提供了宝贵的见解,并表明有必要采用其他治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of The Royal Society Interface
Journal of The Royal Society Interface 综合性期刊-综合性期刊
CiteScore
7.10
自引率
2.60%
发文量
234
审稿时长
2.5 months
期刊介绍: J. R. Soc. Interface welcomes articles of high quality research at the interface of the physical and life sciences. It provides a high-quality forum to publish rapidly and interact across this boundary in two main ways: J. R. Soc. Interface publishes research applying chemistry, engineering, materials science, mathematics and physics to the biological and medical sciences; it also highlights discoveries in the life sciences of relevance to the physical sciences. Both sides of the interface are considered equally and it is one of the only journals to cover this exciting new territory. J. R. Soc. Interface welcomes contributions on a diverse range of topics, including but not limited to; biocomplexity, bioengineering, bioinformatics, biomaterials, biomechanics, bionanoscience, biophysics, chemical biology, computer science (as applied to the life sciences), medical physics, synthetic biology, systems biology, theoretical biology and tissue engineering.
期刊最新文献
A global cross-cultural analysis of string figures reveals evidence of deep transmission and innovation. Trade-off between the antiviral and vaccinal effects of antibody therapy in the humoral response to HIV. Collective effect of self-learning and social learning on language dynamics: a naming game approach in social networks. Correction: 'The three-dimensional coarse-graining formulation of interacting elastohydrodynamic filaments and multi-body microhydrodynamics' (2023), by Fuchter and Bloomfield-Gadêlha. Soft tissue can absorb surprising amounts of energy during knee exoskeleton use.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1