Unraveling the complexity of follicular fluid: insights into its composition, function, and clinical implications.

IF 3.8 3区医学 Q1 REPRODUCTIVE BIOLOGY Journal of Ovarian Research Pub Date : 2024-11-26 DOI:10.1186/s13048-024-01551-9

Yurong Pan, Chenyu Pan, Chunping Zhang

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Abstract

Follicular fluid (FF) plays a vital role in the bidirectional communication between oocytes and granulosa cells (GCs), regulating and promoting oocyte growth and development. This fluid constitutes a complex microenvironment, rich in various molecules including hormones, growth factors, cytokines, lipids, proteins, and extracellular vesicles. Understanding the composition and metabolic profile of follicular fluid is important for investigating ovarian pathologies such as polycystic ovary syndrome (PCOS) and endometriosis. Additionally, analyzing follicular fluid can offer valuable insights into oocyte quality, aiding in optimal oocyte selection for in vitro fertilization (IVF). This review provides an overview of follicular fluid composition, classification of its components and discusses the influential components of oocyte development. It also highlights the role of follicular fluid in the pathogenesis and diagnosis of ovarian diseases, along with potential follicular fluid biomarkers for assessing oocyte quality. By understanding the intricate relationship between follicular fluid and oocyte development, we can advance fertility research and improve clinical outcomes for infertility patients.

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揭开卵泡液的复杂面纱：洞察其成分、功能和临床意义。

卵泡液（FF）在卵母细胞和颗粒细胞（GCs）之间的双向交流、调节和促进卵母细胞的生长和发育方面起着至关重要的作用。这种液体构成了一个复杂的微环境，富含各种分子，包括激素、生长因子、细胞因子、脂质、蛋白质和细胞外囊泡。了解卵泡液的成分和代谢特征对于研究多囊卵巢综合症（PCOS）和子宫内膜异位症等卵巢病变非常重要。此外，分析卵泡液还能提供有关卵母细胞质量的宝贵信息，有助于体外受精（IVF）的最佳卵母细胞选择。本综述概述了卵泡液的组成、成分分类，并讨论了卵母细胞发育的影响因素。它还强调了卵泡液在卵巢疾病的发病机制和诊断中的作用，以及评估卵母细胞质量的潜在卵泡液生物标志物。通过了解卵泡液与卵母细胞发育之间错综复杂的关系，我们可以推进不孕症研究，改善不孕症患者的临床治疗效果。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.