Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage.

IF 4.2 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecules Pub Date : 2024-11-20 DOI:10.3390/molecules29225479

Minseo Kang, Somin Park, So-Ri Son, Yedam Noh, Dae Sik Jang, Sullim Lee

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Abstract

Panax ginseng (Korean ginseng) is renowned for its health-promoting properties, attributed to its bioactive compounds, including saponins, polyphenols, and polysaccharides, which possess both antioxidant and anti-aging activities. This study investigated the anti-aging and anti-inflammatory effects of compounds isolated from the hot water extract of fresh P. ginseng roots, evaluating their resistance to TNF-α/IFN-γ-induced skin cell damage. Among 14 compounds, ginsenoside Rf (compound 2) showed significant multi-target effects. In NHDFs, ginsenoside Rf and others effectively reduced intracellular ROS, demonstrating strong antioxidant properties. Additionally, they inhibited MMP-1 expression, a key enzyme in collagen degradation, and promoted pro-collagen Type I synthesis, countering the negative effects of TNF-α and supporting skin health. Further analysis showed that ginsenoside Rf reduced the secretion of inflammatory cytokines like IL-1β and IL-6, exhibiting anti-inflammatory effects. It also promoted the expression of crucial skin barrier proteins, including LOR, AQP3, FLG, and KRT1 in TNF-α/IFN-γ-stimulated NHEKs, enhancing skin hydration and structural integrity. These results suggest that compounds from P. ginseng roots, especially ginsenoside Rf, hold promise as skincare agents targeting skin aging and inflammation. Future research should further explore their mechanisms and optimize their applications in dermatological treatments.

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新鲜三七根中化合物的抗衰老和抗炎作用：TNF-α/IFN-γ诱导的皮肤细胞损伤研究。

人参（高丽参）因其生物活性化合物（包括皂苷、多酚和多糖）具有抗氧化和抗衰老活性而享有促进健康的美誉。本研究调查了从新鲜人参根热水提取物中分离出来的化合物的抗衰老和抗炎作用，评估了它们对 TNF-α/IFN-γ 诱导的皮肤细胞损伤的抵抗力。在 14 种化合物中，人参皂苷 Rf（化合物 2）显示出显著的多靶点效应。在 NHDFs 中，人参皂苷 Rf 和其他化合物能有效降低细胞内的 ROS，表现出很强的抗氧化性。此外，它们还能抑制胶原蛋白降解的关键酶 MMP-1 的表达，促进促胶原蛋白 I 型的合成，从而抵消 TNF-α 的负面影响，支持皮肤健康。进一步的分析表明，人参皂苷 Rf 能减少 IL-1β 和 IL-6 等炎症细胞因子的分泌，具有抗炎作用。人参皂苷 Rf 还能促进 TNF-α/IFN-γ刺激的 NHEK 中 LOR、AQP3、FLG 和 KRT1 等重要皮肤屏障蛋白的表达，增强皮肤的水合作用和结构完整性。这些结果表明，人参根中的化合物，尤其是人参皂苷 Rf，有望成为针对皮肤老化和炎症的护肤剂。未来的研究应进一步探索其机制，并优化其在皮肤病治疗中的应用。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.