Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study.

IF 2.6 3区医学 Q3 NEUROSCIENCES Neurotoxicology and teratology Pub Date : 2024-11-24 DOI:10.1016/j.ntt.2024.107404

Hailey Modi, David A A Baranger, Sarah E Paul, Aaron J Gorelik, Alana Hornstein, Jared V Balbona, Arpana Agrawal, Janine D Bijsterbosch, Ryan Bogdan

{"title":"Associations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study.","authors":"Hailey Modi, David A A Baranger, Sarah E Paul, Aaron J Gorelik, Alana Hornstein, Jared V Balbona, Arpana Agrawal, Janine D Bijsterbosch, Ryan Bogdan","doi":"10.1016/j.ntt.2024.107404","DOIUrl":null,"url":null,"abstract":"Objective: Though caffeine use during pregnancy is common, its longitudinal associations with child behavioral and physical health outcomes remain poorly understood. Here, we estimated associations between prenatal caffeine exposure, body mass index (BMI), and behavior as children enter adolescence.Method: Longitudinal data and caregiver-reported prenatal caffeine exposure were obtained from the ongoing Adolescent Brain and Cognitive Development (ABCD)SM Study, which recruited 11,875 children aged 9-11 years at baseline from 21 sites across the United States starting June 1, 2016. Prenatal caffeine exposure was analyzed as a 4-level categorical variable, and further group contrasts were used to characterize \"any exposure\" and \"daily exposure\" groups. Outcomes included psychopathology characteristics in children, sleep problems, and BMI. Potentially confounding covariates included familial (e.g., income, familial psychopathology), pregnancy (e.g., prenatal substance exposure), and child (e.g., caffeine use) variables.Results: Among 10,873 children (5686 boys [52.3 %]; mean [SD] age, 9.9 [0.6] years) with nonmissing prenatal caffeine exposure data, 6560 (60 %) were exposed to caffeine prenatally. Relative to no exposure, daily caffeine exposure was associated with higher child BMI (β = 0.08; FDR-corrected p = 0.02), but was not associated with child behavior following correction for multiple testing. Those exposed to two or more cups of caffeine daily (n = 1028) had greater sleep problems than those with lower/no exposure (β > 0.92; FDR-corrected p < 0.04).Conclusion: Daily prenatal caffeine exposure is associated with heightened childhood BMI, and when used multiple times a day greater sleep problems even after accounting for potential confounds. Whether this relationship is a consequence of prenatal caffeine exposure or its correlated factors remains unknown.","PeriodicalId":19144,"journal":{"name":"Neurotoxicology and teratology","volume":" ","pages":"107404"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurotoxicology and teratology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ntt.2024.107404","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Though caffeine use during pregnancy is common, its longitudinal associations with child behavioral and physical health outcomes remain poorly understood. Here, we estimated associations between prenatal caffeine exposure, body mass index (BMI), and behavior as children enter adolescence.

Method: Longitudinal data and caregiver-reported prenatal caffeine exposure were obtained from the ongoing Adolescent Brain and Cognitive Development (ABCD)^SM Study, which recruited 11,875 children aged 9-11 years at baseline from 21 sites across the United States starting June 1, 2016. Prenatal caffeine exposure was analyzed as a 4-level categorical variable, and further group contrasts were used to characterize "any exposure" and "daily exposure" groups. Outcomes included psychopathology characteristics in children, sleep problems, and BMI. Potentially confounding covariates included familial (e.g., income, familial psychopathology), pregnancy (e.g., prenatal substance exposure), and child (e.g., caffeine use) variables.

Results: Among 10,873 children (5686 boys [52.3 %]; mean [SD] age, 9.9 [0.6] years) with nonmissing prenatal caffeine exposure data, 6560 (60 %) were exposed to caffeine prenatally. Relative to no exposure, daily caffeine exposure was associated with higher child BMI (β = 0.08; FDR-corrected p = 0.02), but was not associated with child behavior following correction for multiple testing. Those exposed to two or more cups of caffeine daily (n = 1028) had greater sleep problems than those with lower/no exposure (β > 0.92; FDR-corrected p < 0.04).

Conclusion: Daily prenatal caffeine exposure is associated with heightened childhood BMI, and when used multiple times a day greater sleep problems even after accounting for potential confounds. Whether this relationship is a consequence of prenatal caffeine exposure or its correlated factors remains unknown.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

产前咖啡因暴露与儿童发育之间的关系：青少年大脑认知发展（ABCD）研究的纵向结果。

目的：虽然孕期使用咖啡因很常见，但人们对咖啡因与儿童行为和身体健康结果的纵向关系仍然知之甚少。在此，我们估算了产前咖啡因暴露、体重指数（BMI）和儿童进入青春期后的行为之间的关系：纵向数据和护理人员报告的产前咖啡因暴露来自正在进行的青少年大脑和认知发展（ABCD）SM 研究，该研究从 2016 年 6 月 1 日开始在全美 21 个地点招募了 11,875 名基线年龄为 9-11 岁的儿童。产前咖啡因暴露作为一个四级分类变量进行分析，并进一步进行分组对比，以确定 "任何暴露 "组和 "每日暴露 "组的特征。研究结果包括儿童心理病理学特征、睡眠问题和体重指数。潜在的混杂协变量包括家庭（如收入、家庭精神病理学）、妊娠（如产前药物暴露）和儿童（如咖啡因使用）变量：在产前咖啡因暴露数据无遗漏的10873名儿童（5686名男孩[52.3%]；平均[SD]年龄为9.9[0.6]岁）中，有6560名儿童（60%）在产前接触过咖啡因。与未接触咖啡因相比，每天接触咖啡因与儿童较高的体重指数相关（β = 0.08；经FDR校正后p = 0.02），但经多重检验校正后与儿童行为无关。每天摄入两杯或两杯以上咖啡因的人（n = 1028）比摄入较少/未摄入咖啡因的人有更多的睡眠问题（β > 0.92；FDR校正后的p 结论：与其他儿童相比，每天摄入两杯或两杯以上咖啡因的人（n = 1028）有更多的睡眠问题：即使考虑了潜在的混杂因素，产前每日摄入咖啡因与儿童体重指数（BMI）升高有关，如果每天多次摄入咖啡因，睡眠问题会更严重。这种关系是否是产前咖啡因暴露或其相关因素造成的，目前仍不得而知。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Neurotoxicology and teratology 医学-毒理学

CiteScore

5.60

自引率

10.30%

发文量

审稿时长

58 days

期刊介绍： Neurotoxicology and Teratology provides a forum for publishing new information regarding the effects of chemical and physical agents on the developing, adult or aging nervous system. In this context, the fields of neurotoxicology and teratology include studies of agent-induced alterations of nervous system function, with a focus on behavioral outcomes and their underlying physiological and neurochemical mechanisms. The Journal publishes original, peer-reviewed Research Reports of experimental, clinical, and epidemiological studies that address the neurotoxicity and/or functional teratology of pesticides, solvents, heavy metals, nanomaterials, organometals, industrial compounds, mixtures, drugs of abuse, pharmaceuticals, animal and plant toxins, atmospheric reaction products, and physical agents such as radiation and noise. These reports include traditional mammalian neurotoxicology experiments, human studies, studies using non-mammalian animal models, and mechanistic studies in vivo or in vitro. Special Issues, Reviews, Commentaries, Meeting Reports, and Symposium Papers provide timely updates on areas that have reached a critical point of synthesis, on aspects of a scientific field undergoing rapid change, or on areas that present special methodological or interpretive problems. Theoretical Articles address concepts and potential mechanisms underlying actions of agents of interest in the nervous system. The Journal also publishes Brief Communications that concisely describe a new method, technique, apparatus, or experimental result.