Association of maternal blood metabolomics and gestational diabetes mellitus risk: a systematic review and meta-analysis.

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2025-04-01 Epub Date: 2024-11-27 DOI:10.1007/s11154-024-09934-5
Jing Zhou, Jie Yu, Jing Ren, Yaolin Ren, Yuan Zeng, Yifan Wu, Qian Zhang, Xinhua Xiao
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Abstract

Gestational diabetes mellitus (GDM) is a common complication of pregnancy that has short- and long-term adverse effects. Therefore, further exploration of the pathophysiology of GDM and related biomarkers is important. In this study, we performed a systematic review and meta-analysis to investigate the associations between metabolites in blood detected via metabolomics techniques and the risk of GDM and to identify possible biomarkers for predicting the occurrence of GDM. We retrieved case‒control and cohort studies of metabolomics and GDM published in PubMed, Embase, and Web of Science through March 29, 2024; extracted metabolite concentrations, odds ratios (ORs), or relative risks (RRs); and evaluated the integrated results with metabolites per-SD risk estimates and 95% CIs for GDM. We estimated the results via the random effects model and the inverse variance method. Our study is registered in PROSPERO (CRD42024539435). We included a total of 28 case‒control and cohort studies, including 17,370 subjects (4,372 GDM patients and 12,998 non-GDM subjects), and meta-analyzed 67 metabolites. Twenty-five of these metabolites were associated with GDM risk. Some amino acids (isoleucine, leucine, valine, alanine, aspartate, etc.), lipids (C16:0, C18:1n-9, C18:1n-7, lysophosphatidylcholine (LPC) (16:0), LPC (18:0), and palmitoylcarnitine), and carbohydrates and energy metabolites (glucose, pyruvate, lactate, 2-hydroxybutyrate, 3-hydroxybutyrate) were discovered to be associated with increased GDM risk (hazard ratio 1.06-2.77). Glutamine, histidine, C14:0, and sphingomyelin (SM) (34:1) were associated with lower GDM risk (hazard ratio 0.75-0.84). These findings suggest that these metabolites may play essential roles in GDM progression, and serve as biomarkers, contributing to the early diagnosis and prediction of GDM.

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母体血液代谢组学与妊娠糖尿病风险的关系:系统综述和荟萃分析。
妊娠糖尿病(GDM)是一种常见的妊娠并发症,具有短期和长期的不良影响。因此,进一步探索 GDM 的病理生理学和相关生物标志物非常重要。在本研究中,我们进行了一项系统性回顾和荟萃分析,以研究通过代谢组学技术检测到的血液中代谢物与 GDM 风险之间的关联,并确定预测 GDM 发生的可能生物标志物。我们检索了截至 2024 年 3 月 29 日发表在 PubMed、Embase 和 Web of Science 上的代谢组学与 GDM 的病例对照和队列研究;提取了代谢物浓度、几率比(OR)或相对风险(RR);并评估了代谢物每 SD 风险估计值和 GDM 95% CI 的综合结果。我们通过随机效应模型和反方差法对结果进行了估计。我们的研究已在 PROSPERO 注册(CRD42024539435)。我们共纳入了 28 项病例对照和队列研究,包括 17,370 名受试者(4,372 名 GDM 患者和 12,998 名非 GDM 受试者),并对 67 种代谢物进行了荟萃分析。其中 25 种代谢物与 GDM 风险有关。一些氨基酸(异亮氨酸、亮氨酸、缬氨酸、丙氨酸、天门冬氨酸等)、脂类(C16:C16:C16:C16:C16:C16:C发现一些氨基酸(异亮氨酸、亮氨酸、缬氨酸、丙氨酸、天门冬氨酸等)、脂类(C16:0、C18:1n-9、C18:1n-7、溶血磷脂酰胆碱(LPC)(16:0)、LPC(18:0)和棕榈酰肉碱)以及碳水化合物和能量代谢产物(葡萄糖、丙酮酸、乳酸、2-羟基丁酸、3-羟基丁酸)与 GDM 风险增加有关(危险比为 1.06-2.77)。谷氨酰胺、组氨酸、C14:0 和鞘磷脂(SM)(34:1)与 GDM 风险降低有关(危险比为 0.75-0.84)。这些研究结果表明,这些代谢物可能在 GDM 的发展过程中发挥重要作用,并可作为生物标志物,有助于 GDM 的早期诊断和预测。
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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
期刊最新文献
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