{"title":"Phosphazene base-catalyzed telescopic three-component reaction involving 1,1-difunctionalization of electron-deficient alkenes","authors":"Azusa Kondoh, Sho Yamaguchi, Masahiro Terada","doi":"10.1039/d4cc05169f","DOIUrl":null,"url":null,"abstract":"Phosphazene base, P2-tBu, efficiently catalyzed the telescopic three-component reaction of diethyl phosphite, cinnamonitrile derivatives, and N-Boc imines, providing β-aminophosphonates having a tetrasubstituted carbon in a highly diastereoselective manner. The reaction involves the little-known 1,1-difunctionalization of an electron-deficient alkene, offering a new format for the three-component reaction under Brønsted base catalysis.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"46 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc05169f","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Phosphazene base, P2-tBu, efficiently catalyzed the telescopic three-component reaction of diethyl phosphite, cinnamonitrile derivatives, and N-Boc imines, providing β-aminophosphonates having a tetrasubstituted carbon in a highly diastereoselective manner. The reaction involves the little-known 1,1-difunctionalization of an electron-deficient alkene, offering a new format for the three-component reaction under Brønsted base catalysis.
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