Ileus, pneumonia among most burdensome effects of clozapine treatment

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Abstract

An analysis of longitudinal data with up to 25 years of follow-up has identified five disease categories for which clozapine use was associated with higher risk of adverse drug events. The Finnish study found higher-than-expected prevalence of ileus and pneumonia in patients receiving clozapine, with both illnesses associated with greater mortality.

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腹泻和肺炎是氯氮平治疗带来的最大负担
一项长达25年的纵向随访数据分析确定了五种疾病类别,使用氯氮平与较高的药物不良事件风险相关。芬兰的研究发现,在接受氯氮平治疗的患者中,回肠梗阻和肺炎的发病率高于预期,而这两种疾病都与较高的死亡率有关。
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