Association of Abnormal Body Weight and Allergic Rhinitis-A Systematic Review and Meta-Analysis.

IF 6.3 2区医学 Q1 ALLERGY Clinical and Experimental Allergy Pub Date : 2024-11-27 DOI:10.1111/cea.14604

Brian Sheng Yep Yeo, Elaine Jiaxin Guan, Kaiwen Ng, Yun Sun Lim, Ryan Tsui Hon Goh, Xuandao Liu, Chu Qin Phua, Kaijun Tay, Lu Hui Png, Shuhui Xu, Neville Wei Yang Teo, Tze Choong Charn

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Abstract

Objective: Allergic rhinitis (AR) is a prevalent inflammatory condition of the nasal mucosa, with significant burden worldwide. While studies have demonstrated a relationship between body mass index (BMI) and other atopic diseases, its association with AR is uncertain. This study aims to clarify the association between non-normal BMI and AR.

Design: According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, independent authors screened studies for eligibility, extracted data and assessed bias of included studies using the Newcastle-Ottawa scale and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. A random-effects meta-analysis was used to pool maximally covariate-adjusted estimates. Additional subgroup and bias analyses were performed.

Data sources: PubMed, Embase, Cochrane Library, SCOPUS and CINAHL were searched from inception to 14 January, 2024.

Eligibility criteria: Observational studies investigating the association between non-normal BMI and AR in both children and adults.

Results: We included 32 articles comprising 2,008,835 participants. The risk of bias was low (N = 20) or moderate (N = 12) and GRADE certainty of evidence was very low to low. Pooled cross-sectional analyses indicated that obese children (OR = 0.99, 95% CI = 0.96-1.03, I² = 0%), obese adults (OR = 1.11, 95% CI = 0.92-1.33, I² = 73%), overweight children (OR = 1.02, 95% CI = 0.98-1.06, I² = 35%), and overweight adults (OR = 1.13, 95% CI = 0.90-1.40, I² = 0%) showed similar odds of AR compared to controls. Additionally, longitudinal analyses did not identify any evidence for an association between overweight (OR = 1.03, 95% CI = 0.85-1.24, I² = 29%) or underweight (OR = 1.09, 95% CI = 0.77-1.54, I² = 72%) children and AR risk. These results remained largely robust across various subgroups and sensitivity assessments.

Conclusion: Abnormal BMI may not be associated with AR. This study adds to the expanding literature on the association between non-normal BMI and atopic diseases. Further prospective studies are needed to explore the longitudinal relationship between BMI and AR and the effect of weight loss interventions on AR, given the limits of existing literature.

Trial registration: PROSPERO CRD42024503589.

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体重异常与过敏性鼻炎的关系--系统回顾与元分析。

目的：过敏性鼻炎（AR）是一种普遍存在的鼻粘膜炎症，在全球范围内造成了巨大的负担。研究表明，体重指数（BMI）与其他特应性疾病之间存在关系，但其与过敏性鼻炎之间的关系尚不确定。本研究旨在阐明非正常体重指数与 AR 之间的关系：根据系统综述和荟萃分析首选报告项目（PRISMA）建议，独立作者筛选了符合条件的研究，提取了数据，并使用纽卡斯尔-渥太华量表和推荐、评估、发展和评价分级（GRADE）框架评估了纳入研究的偏倚性。随机效应荟萃分析用于汇集最大协变量调整估计值。另外还进行了亚组和偏倚分析：对 PubMed、Embase、Cochrane Library、SCOPUS 和 CINAHL 进行了检索，检索时间从开始到 2024 年 1 月 14 日：调查儿童和成人非正常体重指数与 AR 之间关系的观察性研究：我们纳入了 32 篇文章，共有 2,008,835 名参与者。偏倚风险为低（20 篇）或中度（12 篇），GRADE 证据确定性为极低至低。汇总的横断面分析表明，与对照组相比，肥胖儿童（OR = 0.99，95% CI = 0.96-1.03，I2 = 0%）、肥胖成人（OR = 1.11，95% CI = 0.92-1.33，I2 = 73%）、超重儿童（OR = 1.02，95% CI = 0.98-1.06，I2 = 35%）和超重成人（OR = 1.13，95% CI = 0.90-1.40，I2 = 0%）出现 AR 的几率相似。此外，纵向分析没有发现任何证据表明超重（OR = 1.03，95% CI = 0.85-1.24，I2 = 29%）或体重不足（OR = 1.09，95% CI = 0.77-1.54，I2 = 72%）儿童与 AR 风险之间存在关联。这些结果在不同的亚组和敏感性评估中基本保持稳定：结论：BMI异常可能与AR无关。这项研究补充了有关非正常体重指数与特应性疾病之间关系的文献。鉴于现有文献的局限性，需要进一步开展前瞻性研究，探讨体重指数与特应性红细胞增多症之间的纵向关系，以及减肥干预措施对特应性红细胞增多症的影响：试验注册：PREMCO CRD42024503589。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Allergy 医学-过敏

CiteScore

10.40

自引率

9.80%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field. In response to the increasing number of quality submissions, since 1996 the journals size has increased by over 30%. Clinical & Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms. Truly international in appeal, Clinical & Experimental Allergy publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.