Acute toxicity and biodistribution assessment of quantum dots conjugated to lectins from Schinus terebinthifolia leaves (SteLL) and Punica granatum sarcotesta (PgTeL).

IF 2.1 4区医学 Q3 CHEMISTRY, MULTIDISCIPLINARY Drug and Chemical Toxicology Pub Date : 2024-11-27 DOI:10.1080/01480545.2024.2433074

Raquel Cordeiro de Oliveira, Abdênego Rodrigues da Silva, Robson Raion de Vasconcelos Alves, Matheus Cavalcanti de Barros, Talita Giselly Dos Santos Souza, Alisson Macário de Oliveira, Leydianne Leite de Siqueira Patriota, Patrícia Maria Guedes Paiva, Fernanda das Chagas Ângelo Mendes Tenório, Paulo Euzébio Cabral Filho, Adriana Fontes, Thiago Henrique Napoleão, Mércia Liane de Oliveira, Elvis Joacir de França

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Abstract

This work reports the in vivo investigation of telluride cadmium quantum dots (CdTe QDs) conjugated to plant lectins from Schinus terebinthifolia (SteLL) and Punica granatum (PgTeL) for acute toxicity and genotoxicity in healthy mice and 24-h biodistribution in sarcoma 180-bearing animals. Acute toxicity data indicated their safety, despite some histopathological alterations. Comet assay revealed that the QDs-PgTeL group presented a higher damage index and frequency of damage than the negative control. The micronucleus test did not reveal a genotoxic effect. The 24-h biodistribution study showed a major uptake of cadmium by the liver, spleen, and kidneys. A greater accumulation of cadmium was found in tumors of the QDs-SteLL group. In conclusion, the biodistribution study showed no influence of the studied lectins in the absorption of QDs by different organs and that the conjugation of SteLL resulted in increased targeting of QDs to sarcoma 180 cells, suggesting a potential theranostic application in cancer.

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量子点与Schinus terebinthifolia叶（SteLL）和Punica granatum sarcotesta（PgTeL）凝集素共轭的急性毒性和生物分布评估。

本研究报告了碲化镉量子点（CdTe QDs）与芨芨草凝集素（SteLL）和石榴凝集素（PgTeL）共轭的体内研究，以了解其在健康小鼠体内的急性毒性和遗传毒性，以及在患有肉瘤 180 的动物体内 24 小时的生物分布情况。急性毒性数据表明它们是安全的，尽管存在一些组织病理学改变。彗星试验显示，QDs-PgTeL 组的损伤指数和损伤频率高于阴性对照组。微核试验没有发现基因毒性效应。24 小时生物分布研究表明，镉主要被肝、脾和肾吸收。在 QDs-SteLL 组的肿瘤中发现了更多的镉积累。总之，生物分布研究表明，所研究的凝集素不会影响不同器官对 QDs 的吸收，SteLL 的共轭作用增加了 QDs 对肉瘤 180 细胞的靶向性，这表明 QDs 有可能应用于癌症的治疗。

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来源期刊

Drug and Chemical Toxicology 医学-毒理学

CiteScore

6.00

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal. Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.