The Relationship Between Preoperative Vitamin D Levels and Keloid Recurrence.

IF 2.3 4区医学 Q2 DERMATOLOGY Journal of Cosmetic Dermatology Pub Date : 2024-11-28 DOI:10.1111/jocd.16687

Da Woon Lee, Kang Daihun, Boram Ha, Da Hye Kim, Choong Hyun Chang, Tae Hwan Park

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Abstract

Background: Keloids, characterized by excessive collagen deposition, often recur despite various treatments. This study explores the association between preoperative serum vitamin D levels and keloid recurrence in a Korean population.

Methods: A retrospective cohort of 160 patients who underwent keloid excision was analyzed. Preoperative serum 25(OH) vitamin D and 1,25(OH)₂ vitamin D levels were measured. Recurrence rates were compared using hierarchical logistic regression, adjusting for potential confounders.

Results: Age was significantly associated with keloid recurrence (OR: 0.934, p = 0.009), indicating older age was linked to lower recurrence risk. No significant association was found between preoperative 25(OH) vitamin D (p = 0.395) and 1,25(OH)₂ vitamin D levels (p = 0.925) and keloid recurrence.

Conclusions: Preoperative vitamin D levels do not predict keloid recurrence in this Korean cohort, while age is a significant predictor. Understanding the multifactorial nature of keloid pathogenesis requires further investigation into other potential risk factors.

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术前维生素 D 水平与瘢痕疙瘩复发之间的关系

背景：瘢痕疙瘩的特点是胶原蛋白过度沉积，尽管采取了各种治疗方法，但仍经常复发。本研究探讨了韩国人群术前血清维生素 D 水平与瘢痕疙瘩复发之间的关系：方法：研究人员对 160 名接受瘢痕疙瘩切除术的患者进行了回顾性队列分析。方法：对160名接受瘢痕疙瘩切除术的患者进行了回顾性队列分析，测量了术前血清25（OH）维生素D和1,25（OH）2维生素D水平。采用层次逻辑回归法比较了复发率，并对潜在的混杂因素进行了调整：结果：年龄与瘢痕疙瘩复发率明显相关（OR：0.934，p = 0.009），表明年龄越大复发风险越低。术前25(OH)维生素D水平（p = 0.395）和1,25(OH)2维生素D水平（p = 0.925）与瘢痕疙瘩复发无明显关联：结论：术前维生素 D 水平并不能预测该韩国队列中的瘢痕疙瘩复发情况，而年龄则是一个重要的预测因素。要了解瘢痕疙瘩发病的多因素性质，还需要进一步研究其他潜在的风险因素。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.