Primary dedifferentiated liposarcoma of the gallbladder: a case report and literature review.

IF 1.6 4区医学 Q2 SURGERY Frontiers in Surgery Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI:10.3389/fsurg.2024.1452144

Lan Wang, Tingting Lin, Yubin Hai, Kai Yu, Fan Bu, Ji Lu, Xiuli Wang, Miao Li, Xiaoju Shi

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Abstract

Background: Liposarcoma (LPS) is a kind of malignancy of soft tissue usually found in the retroperitoneal, limb, or neck region, and some may be detected with delayed symptoms (pain or palpable mass), and less frequently occurs in organs of the digestive system. In contrast, Dedifferentiated liposarcoma (DDLPS) is a common histological subtype of LPS. The present study reported a case of dedifferentiated liposarcoma originating in the gallbladder. Differentiated liposarcoma originating from the gallbladder is rarely reported.

Case description: A 64-year-old female patient presented to our hospital with a painless abdominal mass. Abdominal computed tomography (CT) showed that the gallbladder had lost its normal shape, and a 9.1 cm × 7.1 cm × 12.1 cm mass was seen in the area of the gallbladder fossa and the right upper abdomen below it, which had an irregular morphology, inhomogeneous density, and nodular calcification, with marked inhomogeneous enhancement on enhancement scan. Preoperative tumor markers and liver function indicators were not abnormal. With suspicion of a giant malignant tumor of the gallbladder, she underwent a cholecystectomy combined with abdominal mass resection. After surgery, the tumor and gallbladder, were completely resected, and postoperative pathological results confirmed the diagnosis of dedifferentiated liposarcoma deriving from gallbladder. After surgery, the patient and his family refused to continue treatment. After 15 months follow-up, the patient remains asymptomatic and does not show any signs of recurrence. And she is now under continued follow - up.

Conclusions: Treatment of dedifferentiated liposarcoma is still at exploratory stage, and a lack of clinical evidence for this condition might hinder access to clinical trials and studies. Currently, the treatment of choice for dedifferentiated liposarcoma remains radical resection. In the available clinical studies, there are no robust data to support clinical use of neoadjuvant and adjuvant radiochemotherapy. As with other diseases, the use of radiotherapy and chemotherapy before and after surgery may be a potential future treatment.

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胆囊原发性脂肪肉瘤：病例报告和文献综述。

背景：脂肪肉瘤（LPS）是一种软组织恶性肿瘤，通常发生在腹膜后、四肢或颈部，有的可通过延迟症状（疼痛或可触及肿块）发现，较少发生在消化系统器官。相比之下，脂肪肉瘤中常见的组织学亚型是 "分化型脂肪肉瘤"（Dedifferentiated liposarcoma，DDLPS）。本研究报告了一例起源于胆囊的脂肪肉瘤。起源于胆囊的分化型脂肪肉瘤很少见报道：一名64岁的女性患者因腹部无痛性肿块来我院就诊。腹部计算机断层扫描（CT）显示，胆囊已失去正常形态，胆囊窝区及其下方右上腹可见9.1厘米×7.1厘米×12.1厘米的肿块，形态不规则，密度不均匀，呈结节状钙化，增强扫描呈明显不均匀强化。术前肿瘤标志物和肝功能指标未见异常。由于怀疑是胆囊巨大恶性肿瘤，她接受了胆囊切除术联合腹部肿块切除术。术后病理结果确诊为胆囊衍生的脂肪肉瘤。术后，患者及其家属拒绝继续治疗。经过 15 个月的随访，患者仍然没有任何症状，也没有任何复发迹象。结论：结论：对脂肪肉瘤的治疗仍处于探索阶段，缺乏临床证据可能会阻碍临床试验和研究的进行。目前，治疗脂肪肉瘤的首选方法仍然是根治性切除术。在现有的临床研究中，还没有有力的数据支持新辅助和辅助放化疗的临床应用。与其他疾病一样，在手术前后使用放疗和化疗可能是未来的一种潜在治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Surgery Medicine-Surgery

CiteScore

1.90

自引率

11.10%

发文量

1872

审稿时长

12 weeks

期刊介绍： Evidence of surgical interventions go back to prehistoric times. Since then, the field of surgery has developed into a complex array of specialties and procedures, particularly with the advent of microsurgery, lasers and minimally invasive techniques. The advanced skills now required from surgeons has led to ever increasing specialization, though these still share important fundamental principles. Frontiers in Surgery is the umbrella journal representing the publication interests of all surgical specialties. It is divided into several “Specialty Sections” listed below. All these sections have their own Specialty Chief Editor, Editorial Board and homepage, but all articles carry the citation Frontiers in Surgery. Frontiers in Surgery calls upon medical professionals and scientists from all surgical specialties to publish their experimental and clinical studies in this journal. By assembling all surgical specialties, which nonetheless retain their independence, under the common umbrella of Frontiers in Surgery, a powerful publication venue is created. Since there is often overlap and common ground between the different surgical specialties, assembly of all surgical disciplines into a single journal will foster a collaborative dialogue amongst the surgical community. This means that publications, which are also of interest to other surgical specialties, will reach a wider audience and have greater impact. The aim of this multidisciplinary journal is to create a discussion and knowledge platform of advances and research findings in surgical practice today to continuously improve clinical management of patients and foster innovation in this field.