Clustering of cognitive domains among older persons with HIV.

IF 0.6 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Gaceta medica de Mexico Pub Date : 2024-01-01 DOI:10.24875/GMM.23000423

Virgilio Hernández-Ruiz, Carlos A Ruiz-Manríquez, Omar Y Bello-Chavolla, Hélène Amieva, José A Avila-Funes

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Abstract

Background: Age and HIV are synergistic risk factors for conditions such as HIV-associated neurocognitive disorders (HAND). Yet, it is unclear whether older persons with HIV (OPWH) display different cognitive profiles for HAND.

Objective: To describe the cognitive patterns of OPWH treated with combined antiretroviral therapy (cART).

Methods: Cross-sectional study that included 330 participants with HIV, aged 50 years or older, cared for at a tertiary care hospital in Mexico City. A short neuropsychological test battery was used to assess a wide spectrum of cognitive functions. The optimal number of cognitive clusters was determined by the silhouette method and a minimization of the Bayesian information criterion.

Results: Participants' mean age was 58.8 years (standard deviation = 6.6), and 12.1% were women. A 3-cluster solution yielded stable Jaccard coefficients (p > 0.70). Cluster 1 showed more significant impairment in visual and verbal memory domains, whereas participants in cluster 3 showed significant impairment in language, and abstraction. Cluster 2 showed no predominance of any domain for alterations.

Conclusions: There are different cognitive profiles among OAWH with HAND. These differences may be due to individual patterns of HIV-related and non-HIV-related factors.

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感染艾滋病毒的老年人认知领域的聚类。

背景：年龄和艾滋病毒是导致艾滋病毒相关神经认知障碍（HAND）等疾病的协同风险因素。然而，目前尚不清楚老年艾滋病病毒感染者（OPWH）是否对 HAND 有不同的认知模式：描述接受联合抗逆转录病毒疗法（cART）治疗的老年艾滋病患者的认知模式：横断面研究：包括 330 名年龄在 50 岁或以上、在墨西哥城一家三级医院接受治疗的 HIV 感染者。研究使用了一套简短的神经心理学测试来评估各种认知功能。通过剪影法和贝叶斯信息标准最小化法确定了认知群组的最佳数量：参与者的平均年龄为 58.8 岁（标准差 = 6.6），12.1% 为女性。3 个聚类的解决方案产生了稳定的 Jaccard 系数（p > 0.70）。第 1 群组在视觉和语言记忆领域表现出更明显的障碍，而第 3 群组的参与者则在语言和抽象领域表现出明显的障碍。第 2 组在任何领域的改变都不占优势：结论：患有手足徐动障碍的 OAWH 在认知能力方面存在差异。结论：患有手足徐动障碍的 OAWH 之间存在不同的认知状况，这些差异可能是由于与 HIV 相关和非 HIV 相关因素的个体模式造成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gaceta medica de Mexico 医学-医学：内科

CiteScore

1.00

自引率

0.00%

发文量

216

审稿时长

6-12 weeks

期刊介绍： Gaceta Médica de México México is the official scientific journal of the Academia Nacional de Medicina de México, A.C. Its goal is to contribute to health professionals by publishing the most relevant progress both in research and clinical practice. Gaceta Médica de México is a bimonthly peer reviewed journal, published both in paper and online in open access, both in Spanish and English. It has a brilliant editorial board formed by national and international experts.