Relationship between stroke and estimated glucose disposal rate: results from two prospective cohort studies.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2024-11-28 DOI:10.1186/s12944-024-02385-6

Yutong Han, Kexin Zhang, Yue Luo, Bin Wan, Yaowen Zhang, Qinchuan Huang, Hanyu Liu, Yulin Leng, Chunguang Xie

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Abstract

Background: Insulin resistance (IR) is a recognized contributor to stroke association, and the estimated glucose disposal rate (eGDR) is a dependable indicator of IR. However, the specific connections between eGDR, stroke prevalence, and overall mortality have not been thoroughly investigated. This study aimed to examine how eGDR correlates with stroke and overall death rate.

Methods: The study leveraged information from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016. To unravel the data, the team utilized logistic regression, cox proportional hazards models, and restricted cubic splines (RCS) Sensitivity analyses excluded participants with a stroke history within the previous two years. Results were validated through analysis of the China Health and Retirement Longitudinal Study (CHARLS).

Results: A higher eGDR is like a protective shield against strokes, with those in the top eGDR quartile exhibited a 60% reduction in stroke association (OR = 0.40, 95% CI, 0.22-0.73, P = 0.003). Additionally, a higher eGDR correlates with a lower overall death rate (HR = 0.71, 95% CI, 0.52-0.98, P = 0.037), particularly in individuals without a history of stroke. RCS analysis demonstrated that eGDR's influence on stroke association follows a non-linear pattern. Subgroup analysis revealed that the protective effect of eGDR was stronger in non-diabetic and non-hypertensive individuals.

Conclusion: eGDR is inversely related to both stroke association and mortality, affirming its utility as a predictive marker of stroke.

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中风与估计葡萄糖处置率之间的关系：两项前瞻性队列研究的结果。

背景：胰岛素抵抗（IR）是导致中风的一个公认因素，而估计葡萄糖处置率（eGDR）是 IR 的可靠指标。然而，eGDR、中风发病率和总死亡率之间的具体联系尚未得到深入研究。本研究旨在探讨 eGDR 与中风和总死亡率之间的相关性：研究利用了美国国家健康与营养调查（NHANES）的信息，时间跨度为 2007 年至 2016 年。为了揭示数据，研究小组采用了逻辑回归、Cox比例危险模型和限制性立方样条（RCS）等方法进行敏感性分析。结果通过对中国健康与退休纵向研究（CHARLS）的分析得到验证：较高的 eGDR 就像预防中风的保护罩，eGDR 最高的四分位数人群中风相关性降低了 60%（OR = 0.40，95% CI，0.22-0.73，P = 0.003）。此外，较高的 eGDR 与较低的总死亡率相关（HR = 0.71，95% CI，0.52-0.98，P = 0.037），尤其是在无中风史的人群中。RCS 分析表明，eGDR 对中风相关性的影响呈非线性模式。亚组分析表明，eGDR 对非糖尿病和非高血压患者的保护作用更强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.