Michael Konney Laryea, Kofi Mensah Wonder Abotsi, Eric Woode, Rita Akosua Dickson, Lauren Webster, Edmund Ekuadzi
{"title":"Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from <i>Picralima nitida</i>.","authors":"Michael Konney Laryea, Kofi Mensah Wonder Abotsi, Eric Woode, Rita Akosua Dickson, Lauren Webster, Edmund Ekuadzi","doi":"10.1080/14786419.2024.2434710","DOIUrl":null,"url":null,"abstract":"<p><p>Eight monoterpene indole alkaloids (<b>1</b>-<b>8</b>), including one new picraline-type alkaloid, 2-hydroxyakuammiline (<b>4</b>) and seven known compounds: akuammigine (<b>1</b>), akuammine (<b>2</b>), akuammidine (<b>3</b>), akuammiline (<b>5a</b>), akuammiline N-oxide (<b>5b</b>), akuammiline (<b>6</b>), rhazimol (<b>7</b>), and alstonine (<b>8</b>) were isolated from the seeds of <i>Picralima nitida</i>. Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds <b>1</b>-<b>7</b> were moderate. Compound <b>8</b> showed significant effects with pXC50 of 6.3. Compounds <b>1</b> and <b>7</b> showed significant trypanocidal effects with pXC50's of 5.1 and 5.4 respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2434710","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Eight monoterpene indole alkaloids (1-8), including one new picraline-type alkaloid, 2-hydroxyakuammiline (4) and seven known compounds: akuammigine (1), akuammine (2), akuammidine (3), akuammiline (5a), akuammiline N-oxide (5b), akuammiline (6), rhazimol (7), and alstonine (8) were isolated from the seeds of Picralima nitida. Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds 1-7 were moderate. Compound 8 showed significant effects with pXC50 of 6.3. Compounds 1 and 7 showed significant trypanocidal effects with pXC50's of 5.1 and 5.4 respectively.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
