Clinical Effect Analysis and Prognostic Factors of Photodynamic Therapy for Cervical Precancerous Lesions.

Journal of biophotonics Pub Date : 2024-11-28 DOI:10.1002/jbio.202400454

Hong Zhu, Xiangrui Guo, Xu Li, Mengran Chang, Zhongyin Zhang, Junjun Dai

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Abstract

Objective: To evaluate the therapeutic effect of photodynamic therapy (PDT) on cervical precancerous lesions and prognostic factors.

Methods: 173 patients diagnosed with cervical precancerous lesions and treated with PDT were included. Univariate analysis was performed on human papillomavirus (HPV) infection, patient age, number of treatments and number of medications before and after treatment, to evaluate the efficacy, adverse reactions and patient satisfaction.

Results: 112 patients (64.5%) showed HPV clearance afrer PDT. Age ≥ 40 years was positively correlated with poor prognosis and number of treatments ≥ 6 was negatively correlated with poor prognosis. The satisfaction rate reached 94.79%, with 6 patients experiencing tolerable pain and no treatment discontinuations due to adverse reactions.

Conclusion: PDT is effective and safe for treating cervical precancerous lesions, with patient age and treatment frequency impacting outcomes. High patient satisfaction and tolerable adverse reactions support the application of PDT in clinical practice.

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光动力疗法治疗宫颈癌前病变的临床效果分析和预后因素

目的：评估光动力疗法（PDT）对宫颈癌前病变的治疗效果及预后因素：评估光动力疗法（PDT）对宫颈癌前病变的治疗效果及预后因素。对人类乳头瘤病毒（HPV）感染、患者年龄、治疗次数和治疗前后用药次数进行单变量分析，以评估疗效、不良反应和患者满意度：112名患者（64.5%）在PDT治疗后清除了HPV。年龄≥40岁与预后不良呈正相关，治疗次数≥6次与预后不良呈负相关。满意率达到 94.79%，6 名患者的疼痛可以忍受，没有因不良反应而中断治疗：结论：光动力疗法治疗宫颈癌前病变有效且安全，但患者年龄和治疗频率会影响治疗效果。患者的高满意度和可耐受的不良反应支持了光动力疗法在临床实践中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of biophotonics

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