Synthesis, physicochemical properties and in vitro cytotoxic activity of aziridine-containing derivatives of 1,3,5-triazine

IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Mendeleev Communications Pub Date : 2024-11-01 DOI:10.1016/j.mencom.2024.10.028
Olga V. Mikolaichuk , Alexandra V. Protas , Elena A. Popova , Olga S. Shemchuk , Mikhail D. Luttsev , Daler R. Dadadzhanov , Tigran A. Vartanyan , Andrey V. Petrov , Vladimir V. Sharoyko , Konstantin N. Semenov , Oleg E. Molchanov , Dmitrii N. Maistrenko
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Abstract

6-{[4-(Aziridin-1-yl)-6-chloro-1,3,5-triazin-2-yl]amino}-hexanoic acid methyl ester and sodium salt were synthesized from cyanuric chloride. The sodium salt would interact with free radicals of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and inhibit hemolysis induced by Radachlorin. Both compounds interact with DNA with Kbin values of 1.09 × 107 and 0.99 × 107 dm3 mol−1, respectively; they also demonstrate cytotoxic activity against human cancer cell lines.

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1,3,5-三嗪含氮吡啶衍生物的合成、理化性质及体外细胞毒活性
以三氯氰尿酸为原料合成了6-{[4-(亚氮啶-1-基)-6-氯-1,3,5-三嗪-2-基]氨基}-己酸甲酯和钠盐。钠盐可与2,2-二苯基-1-吡啶酰肼(DPPH)自由基相互作用,抑制Radachlorin诱导的溶血。两种化合物与DNA相互作用的Kbin值分别为1.09 × 107和0.99 × 107 dm3 mol−1;它们还显示出对人类癌细胞系的细胞毒活性。
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Mendeleev Communications
Mendeleev Communications 化学-化学综合
CiteScore
3.00
自引率
21.10%
发文量
226
审稿时长
4-8 weeks
期刊介绍: Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.
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