The target rulings the oxidation and degradation ability of the ZIF-67/PtPd: A seesaw-like two-channel colorimetric platform for organophosphorus detection

Abstract

Herein, the seesaw-like two channels colorimetric platform constructed for organophosphorus pesticides (OPs) determination was based on the dual functions of ZIF-67/PtPd (ZP), which could participate not only in the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB), but also in the degradation of methylene blue (MB). Then the thiocholine (TCh) generated by the reaction of acetylcholinesterase (AChE) and acetylcholine (ATCh) could inhibit the two processes (TMB channel and MB channel), resulting in the color reversal of the two channels, respectively. Additionally, the target OPs could inhibit the AChE activity, leading to decrease the TCh production, so the inhibitory effect of TCh on two channels was weaken, thus affecting the output of the signal value. Based on it, the developed platform exhibited outstanding ability to detect AChE and OPs. Besides, as alkaloids could inhibit AChE, as same as OPs, so the platform have a potential to screen the AChE inhibitors from natural alkaloids.