Violation of auditory regularities is reflected in pupil dynamics

Abstract

The brain builds and maintains internal models and uses them to make predictions. When predictions are violated, the current model can either be updated or replaced by a new model. The latter is accompanied by pupil dilation responses (PDRs) related to locus coeruleus activity/norepinephrine release (LC-NE). Following earlier research, we investigated PDRs associated with transitions between regular and random patterns of tones in auditory sequences. We presented these sequences to participants and instructed them to find gaps (to maintain attention). Transitions from regular to random patterns induced PDRs, suggesting that an internal model attuned to the regular pattern is reset. Transitions from one regular pattern to another regular pattern also induced PDRs, suggesting that they also led to a model reset. In contrast, transitions from random patterns to regular patterns did not induce PDRs, suggesting a gradual update of model parameters. We modelled these findings, using pupil response functions to show how ongoing PDRs and pupil event rates were sensitive to the trial-by-trial changes in the information content of the auditory sequences. Expanding on previous research, we suggest that PDRs—as biomarkers for LC-NE activation—may indicate the extent of prediction violations.