Ning Xu , Haiyan Gao , Yanran Wang , Chenxuan Liu , Lei Hu , Aiyong He , Wankui Jiang , Fengxue Xin
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引用次数: 0
Abstract
In order to achieve the sustainable development of society and reduce environmental footprint of chemical industry, some cleaner and greener production methods are still needed. Microbial fermentation has shown great potentials for sustainable production of chemicals, which can convert renewable resources into different products under mild conditions. Particularly, organic acids production has become a highly competitive and rapidly developed field, as they show broad applications in food, cosmetic and medical areas. Especially, yeasts have shown many advantages in organic acids production especially at high osmotic pressure or low pH. Accordingly, this review will discuss the latest progress of engineered yeasts as cell factories for organic acids production. Different strategies for improvement of organic acids production will be introduced, and future perspectives will also be proposed.
期刊介绍：
The Biochemical Engineering Journal aims to promote progress in the crucial chemical engineering aspects of the development of biological processes associated with everything from raw materials preparation to product recovery relevant to industries as diverse as medical/healthcare, industrial biotechnology, and environmental biotechnology.
The Journal welcomes full length original research papers, short communications, and review papers* in the following research fields:
Biocatalysis (enzyme or microbial) and biotransformations, including immobilized biocatalyst preparation and kinetics
Biosensors and Biodevices including biofabrication and novel fuel cell development
Bioseparations including scale-up and protein refolding/renaturation
Environmental Bioengineering including bioconversion, bioremediation, and microbial fuel cells
Bioreactor Systems including characterization, optimization and scale-up
Bioresources and Biorefinery Engineering including biomass conversion, biofuels, bioenergy, and optimization
Industrial Biotechnology including specialty chemicals, platform chemicals and neutraceuticals
Biomaterials and Tissue Engineering including bioartificial organs, cell encapsulation, and controlled release
Cell Culture Engineering (plant, animal or insect cells) including viral vectors, monoclonal antibodies, recombinant proteins, vaccines, and secondary metabolites
Cell Therapies and Stem Cells including pluripotent, mesenchymal and hematopoietic stem cells; immunotherapies; tissue-specific differentiation; and cryopreservation
Metabolic Engineering, Systems and Synthetic Biology including OMICS, bioinformatics, in silico biology, and metabolic flux analysis
Protein Engineering including enzyme engineering and directed evolution.
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