Frontal neurodegeneration associated with Frontal Assessment Battery in early Alzheimer's disease

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Journal of the Neurological Sciences Pub Date : 2024-11-23 DOI:10.1016/j.jns.2024.123327

Tatsuhiro Terada , Manabu Kubota , Jun Miyata , Tomokazu Obi , Hirotsugu Takashima , Takashi Matsudaira , Tomoyasu Bunai , Yasuomi Ouchi , Toshiya Murai

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Abstract

Background

The Frontal Assessment Battery (FAB) is widely used to assess executive dysfunction in patients with amnestic mild cognitive impairments due to Alzheimer's disease (aMCI-AD), but its neurobiological meaning is unclear. To elucidate this, we examined the relationship between the FAB score and three key imaging biomarkers: gray matter volume, amyloid-beta (Aβ) deposition, and glucose metabolism.

Methods

Twenty Aβ- and tau-positive aMCI-AD patients and age-matched controls underwent structural magnetic resonance imaging and positron emission tomography with [¹¹C]PiB and [¹⁸F]FDG. Voxel-based morphometry and statistical parametric mapping analyses were performed to elucidate the relationships between FAB scores and regional gray matter volume, [¹¹C]PiB uptake for Aβ deposition, and [¹⁸F]FDG uptake for glucose metabolism.

Results

FAB scores were significantly lower in aMCI-AD than in controls (p < 0.001). In aMCI-AD, FAB was significantly correlated with right inferior frontal gray matter volume and right medial and left middle frontal glucose metabolism (family-wise error p < 0.05). However, there was no correlation between Aβ deposition and FAB (family-wise error p < 0.05).

Conclusions

The decreased FAB score is linked more with frontal-lobe neurodegeneration than with Aβ pathology in aMCI-AD. The FAB could be an early marker for neurodegeneration related to frontal-lobe executive dysfunction.

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早期阿尔茨海默病与额叶评估电池相关的额叶神经退行性变

额叶评估电池（FAB）被广泛用于评估因阿尔茨海默病（aMCI-AD）引起的遗忘性轻度认知障碍患者的执行功能障碍，但其神经生物学意义尚不清楚。为了阐明这一点，我们研究了FAB评分与三个关键成像生物标志物之间的关系：灰质体积、β淀粉样蛋白（Aβ）沉积和葡萄糖代谢。方法20例Aβ和tau阳性的aMCI-AD患者和年龄匹配的对照组分别采用[11C]PiB和[18F]FDG进行结构磁共振成像和正电子发射断层扫描。采用基于体素的形态计量学和统计参数映射分析来阐明FAB评分与区域灰质体积、[11C] α β沉积的PiB摄取和[18F]葡萄糖代谢的FDG摄取之间的关系。结果aMCI-AD患者fab评分显著低于对照组(p <；0.001)。在aMCI-AD中，FAB与右下额叶灰质体积、右中额叶和左中额叶葡萄糖代谢显著相关(家族误差p <；0.05)。然而，Aβ沉积与FAB之间没有相关性(家族误差p <；0.05)。结论aMCI-AD患者FAB评分下降与额叶神经退行性变的关系大于与Aβ病理的关系。FAB可能是与额叶执行功能障碍相关的神经退行性变的早期标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Neurological Sciences 医学-临床神经学

CiteScore

7.60

自引率

2.30%

发文量

313

审稿时长

22 days

期刊介绍： The Journal of the Neurological Sciences provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. JNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). JNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism.