Cascade-Responsive Upconversion Nanoplatform for Efficient Cell Nucleus Targeting and Boosted Photodynamic Tumor Therapy

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2024-10-31 DOI:10.1021/acsmaterialslett.4c0161410.1021/acsmaterialslett.4c01614

Bo Ling, Lijiao Yang, Chenchen Wang, Ling Dong, Yanyun Yang, Lun Wang, Jia Zhang and Yue Yuan*,

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Abstract

In order to increase tumor tissue penetration, enhance phototherapy efficiency, and reduce off-target toxicity, we have developed a dual-locked upconversion nanoplatform (UCNP@Glu-DMMA) with a charge-reversal property for tumor-specific, cell nucleus-penetrating photodynamic therapy (PDT). The negative charge on the surface of UCNP@Glu-DMMA ensured excellent stability during blood circulation and accumulation in the tumor microenvironment (TME). Subsequently, the combined effect of the acidic TME and γ-glutamyl transpeptidase (GGT) triggered a reversal of the surface charge from negative to positive. This reversal enhanced the uptake efficiency of UCNP, leading to an increased intracellular drug concentration, deep tumor penetration, and direct nucleus delivery for the localized release of reactive oxygen species, resulting in robust DNA damage. As a result, the efficacy of PDT was significantly and precisely boosted for GGT-overexpressed tumors. This work provides a promising strategy to engineer therapeutic platforms for managing a variety of diseases based on different biomarkers.

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.

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