The causal association between plasma caffeine and frailty: A two-sample mendelian randomization study

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2024-11-26 DOI:10.1016/j.archger.2024.105706

Yuze Mi , Shaokai Lin , Ke Chen , Zhendi Shu

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Abstract

Background

Frailty is one of the most common and challenging consequences of aging, which negatively affects older adults, their families, and society. Caffeine has been shown to be associated with a reduced risk of frailty by observational studies, yet its causal relationship with frailty remains to be tested using more robust methods.

Aims

This study aimed to explore the causal association between plasma caffeine and frailty using a two-sample Mendelian Randomization (MR) analysis.

Methods

Single nucleotide polymorphisms related to plasma caffeine concentrations were selected as instrumental variables. Data on the Frailty Index (FI) were sourced from the UK Biobank and TwinGen meta-analysis (n = 175,226), while data on the Fried Frailty Score (FFS) were obtained from the UK Biobank (n = 386,565). The causal association between plasma caffeine levels and frailty was tested using five MR methods, with the inverse-variance weighted method as the primary approach.

Results

Our results consistently showed significantly negative associations between genetically predicted plasma caffeine with FI (β = -0.050, 95 % CI:0.077 to -0.023, P < 0.001) and FFS (β = -0.049, 95 % CI:0.064 to -0.034, P < 0.001). These results remained robust in further sensitivity analyses using a leave-one-out approach.

Conclusion

Our findings confirm a causal relationship between plasma caffeine and frailty and suggest that increasing plasma caffeine levels may help prevent and reduce the risk of frailty.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.