Shitao Liu, Chixian He, Guijun Li, Yanling Xu, Xianfu Shen, Teng Liu
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引用次数: 0
Abstract
A concise and practicable route to the synthesis of multisubstituted 2-pyridones via a four-component one-pot stepwise cyclization catalyzed by Cs2CO3 has been developed. During this stepwise transformation, two new C-C bonds and two new C-N bonds were generated through an intermolecular condensation/aza-Michael reaction/intermolecular Michael addition/intramolecular cyclization sequence. The alternative protocol offers a complementary route to provide a series of structurally diverse polysubstituted 2-pyridones (21 examples) in good to excellent yields (52–81%) from easily available raw materials arylamines, dialkyl acetylenedicarboxylate, 1,3-dicarbonyl compounds, and trialkyl orthoformate under mild conditions. It might provide new opportunities for the discovery of 2-pyridones-containing drugs.
期刊介绍：
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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